Kitamycin C, a new antimycin-type antibiotic from Streptomyces antibioticus strain 200-09
文献类型： 外文期刊
作者： Wang, Fan 1 ; Fu, Shu-Na 1 ; Bao, Yi-Xuan 1 ; Yang, Yu 1 ; Shen, Hui-Fang 2 ; Lin, Bi-Run 2 ; Zhou, Guang-Xiong 1 ;
作者机构： 1.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou, Guangdong, Peoples R China
2.Guangdong Acad Agr Sci, Inst Plant Protect, Key Lab New Tech Plant Protect Guangdong, Guangzhou, Guangdong, Peoples R China
关键词： Streptomyces antibioticus;kitamycin C;antimycin;antifungal activity
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）
ISSN： 1478-6419
年卷期： 2017 年 31 卷 15 期
页码：
收录情况： SCI
摘要： An actinomycete strain 200-09, isolated from a soil sample collected from the coast of Hawaii, USA, was identified as Streptomyces antibioticus on the basis of its morphological, physiological and biochemical characteristics as well as 16S rDNA analysis. A new antimycin-type antibiotic, kitamycin C (1), together with kitamycin A (2), kitamycin B (3), urauchmycin B (4), deisovaleryblastomycin (5) was isolated from a cultured broth of strain 200-09. The structure of the new compound was determined by spectroscopic data, including HR-ESI-MS and NMR. All the compounds exhibited antifungal activities against Candida albicans with MIC of about 25.0gmL(-1). [GRAPHICS] .
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