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High genetic and antigenic similarity between a swine H3N2 influenza A virus and a prior human influenza vaccine virus: A possible immune pressure-driven cross-species transmission

文献类型： 外文期刊

作者： Pan, Chungen 1 ; Wang, Guiping 2 ; Liao, Ming 3 ; Zhang, Gui-Hong 3 ; Jiang, Shibo 1 ;

作者机构： 1.New York Blood Ctr, Lindsley F Kimball Res Inst, New York, NY 10065 USA

2.Guangdong Acad Agr Sci, Inst Vet Med, Guangzhou 510640, Peoples R China

3.So China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China

关键词： Influenza;Influenza A virus;H3N2;H1N1;Genetic similarity;Antigen drift;Immune pressure;Cross-species transmission

期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.575； 五年影响因子：3.381 ）

ISSN： 0006-291X

年卷期： 2009 年 385 卷 3 期

页码：

收录情况： SCI

摘要： In late April of 2009, a global outbreak of human influenza was reported. The causative agent is a highly unusual reassortant H1N1 influenza virus carrying genetic segments derived from swine, human and avian influenza viruses. In this study, we compared the HA, NA and other gene segments of a swine H3N2 influenza A virus, A/Swine/Guangdong/z5/2003, which was isolated from pigs in 2003 in Guangdong Province, China, to the predominant human and swine H3N2 viruses. We found that the similarity of gene segments of A/Swine/Guangdong/z5/2003 was closer to Moscow/99-like human H3N2 virus than Europe swine H3N2 viruses during 1999-2002. These results suggest that A/Swine/Guangdong/z5/2003 may be Porcine in origin, possibly being driven by human immune pressure induced by either natural H3N2 virus infection or use of A/Moscow/10/99 (H3N2)-based human influenza vaccine. The results further confirm that swine may play a dual role as a "shelter" for hosting influenza virus from humans or birds and as a "mixing vessel" for generating reassortant influenza viruses. such as the one causing current influenza pandemic. (C) 2009 Elsevier Inc. All rights reserved.

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