Flavonoids in vegetables: improvement of dietary flavonoids by metabolic engineering to promote health
文献类型： 外文期刊
作者： Tao, Han 1 ; Li, Linying 1 ; He, Yuqing 1 ; Zhang, Xueying 1 ; Zhao, Yao 1 ; Wang, Qiaomei 2 ; Hong, Gaojie 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Virol & Biotechnol,Key Lab Biotechnol Plant, Key Lab Managing Biot & Chem Threats Qual & Safet, Key Lab Biotechnol Plant Protect,Minist Agr & Rur, Hangzhou, Zhejiang, Peoples R China
2.Zhejiang Univ, Coll Agr & Biotechnol, Dept Hort, Hangzhou, Zhejiang, Peoples R China
3.Minist Agr, Key Lab Hort Plant Growth Dev & Qual Improvement, Hangzhou, Zhejiang, Peoples R China
关键词： Antioxidants; flavonoids; metabolic engineering; vegetables
期刊名称：CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION （ 影响因子：11.208； 五年影响因子：12.104 ）
ISSN： 1040-8398
年卷期：
页码：
收录情况： SCI
摘要： Flavonoids are the most abundant polyphenols in plants, and have antioxidant effects as well as other bioactivities (e.g., anti-inflammatory, anti-cancer, anti-allergic, and neuroprotective effects). Vegetables are rich in flavonoids and are indispensable in our daily diet. Moreover, the vegetables as chassis for producing natural products would emerge as a promising means for cost-effective and sustainable production of flavonoids. Understanding the metabolic engineering of flavonoids in vegetables allows us to improve their nutrient composition. In this review, a comprehensive overview of flavonoids in vegetables, including the characterized types and distribution, health-promoting effects, associated metabolic pathways, and applied metabolic engineering are provided. We also introduce breakthroughs in multi-omics approaches that pertain to the elucidation of flavonoids metabolism in vegetables, as well as prospective and potential genome-editing technologies. Based on the varied composition and content of flavonoids among vegetables, dietary suggestions are further provided for human health.
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