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Production of Antifungal p-Aminobenzoic Acid in Lysobacter antibioticus OH13

文献类型: 外文期刊

作者: Laborda, Pedro 1 ; Zhao, Yangyang 1 ; Ling, Jun 1 ; Hou, Rongxian 1 ; Liu, Fengquan 1 ;

作者机构: 1.Jiangsu Acad Agr Sci, Inst Plant Protect, Nanjing 210014, Peoples R China

关键词: biocontrol;Lysobacter;antifungal activity;p-aminobenzoic acid production

期刊名称:JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY ( 影响因子:5.279; 五年影响因子:5.269 )

ISSN: 0021-8561

年卷期: 2018 年 66 卷 3 期

页码:

收录情况: SCI

摘要: Among Lysobacter species, Lysobacter antibioticus has been demonstrated to be an interesting source of antimicrobial metabolites for the biocontrol of plant diseases. Although the antibacterial activity was attributed to N-oxide phenazines, the active compounds involved in the antifungal function remained unknown. In this work, an antifungal compound was isolated and identified as p-aminobenzoic acid (pABA). Antifungal activity screening revealed that pABA shows activity against a number of plant pathogens. The genes involved in the synthetic route of this compound in OH13 were identified. Further, the production of pABA was optimized by modification of the carbon source using engineered L. antibioticus OH13 strains.

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