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MXene/zinc ion embedded agar/sodium alginate hydrogel for rapid and efficient sterilization with photothermal and chemical synergetic therapy

文献类型： 外文期刊

作者： Hu, Yuwei 1 ; Zeng, Qin 1 ; Hu, Yifan 3 ; Wang, Heye 4 ; Deng, Chunyan 1 ; Li, Dai 2 ;

作者机构： 1.Cent South Univ, Coll Chem & Chem Engn, Hunan Prov Key Lab Micro & Nano Mat Interface Sci, Changsha 410083, Peoples R China

2.Cent South Univ, Xiangya Hosp, Phase Clin Trial Ctr 1, Changsha 410008, Peoples R China

3.Naval Med Univ, Coll Basic Med Sci, Shanghai 200433, Peoples R China

4.Jiangsu Acad Agr Sci, Key Lab Food Qual & Safety Jiangsu Prov, State Key Lab Breeding Base, Inst Food Safety & Nutr, Nanjing 210000, Peoples R China

关键词： Agar/sodium alginate hydrogel; Antibacterial photothermal therapy; Sterilization treatment; Wound dressing

期刊名称：TALANTA （ 影响因子：6.1； 五年影响因子：5.4 ）

ISSN： 0039-9140

年卷期： 2024 年 266 卷

页码：

收录情况： SCI

摘要： Bacterial infections can significantly impair wound healing. Therefore, it is essential to develop wound dressings with high antimicrobial activity. Hydrogels are often used as wound dressings due to their excellent physicochemical properties. Herein, by cross linking sodium alginate (SA), agar (AG) with Ti3C2Tx MXene and Zinc ions (Zn2+), a biosafe composite hydrogel (MSG-Zn2+) was developed for fast and efficient sterilization treatment. The excellent photothermal properties of Ti3C2Tx MXene and the chemical antimicrobial activity of Zn2+ enable synergistic photothermal therapy (PTT)/chemical therapy in NIR biowindow with reduced power density and improved antimicrobial efficiency. More importantly, the incorporation of Zn2+ can enhance the effective contact between the hydrogel and bacteria, benefiting both photothermal and chemical antibacteria. In vitro antibacterial experiments showed that MSG-Zn2+ has a broad-spectrum antibacterial effect against Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli). Cellular experiments showed that the hydrogel had excellent biocompatibility and the released Zn2+ stimulated cell migration. In addition, the prepared MSG-Zn2+ hydrogel has other advantages such as hydrophilic, high swelling, simple and low cost preparation, which meets the requirements of an economical wound dressing. This proposed work shows that this composite hydrogel MSG-Zn2+ has great potential for practical antimicrobial wound dressing applications.

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