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Salidroside liposome formulation enhances the activity of dendritic cells and immune responses

文献类型： 外文期刊

作者： Zhao, Xiaojuan 1 ; Lu, Yu; Tao, Yang 1 ; Huang, Yee 1 ; Wang, Deyun 1 ; Hu, Yuanliang 1 ; Liu, Jiaguo 1 ; Wu, Yi 1 ; Yu, 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Inst Tradit Chinese Vet Med, Nanjing 210095, Jiangsu, Peoples R China

2.Jiangsu Acad Agr Sci, Natl Res Ctr Vet Biol Engn & Technol, Nanjing 210014, Jiangsu, Peoples R Ch

关键词： Salidroside liposomes;Dendritic cells;OVA;Vaccine;Adjuvant

期刊名称：INTERNATIONAL IMMUNOPHARMACOLOGY （ 影响因子：4.932； 五年影响因子：4.624 ）

ISSN： 1567-5769

年卷期： 2013 年 17 卷 4 期

页码：

收录情况： SCI

摘要： Salidroside, the important composition, of Rhodiola rosea L has been reported to have various pharmacological properties. Liposome is known to be effective as drug carriers and immune adjuvant Therefore, the aim of this study is to investigate immunological adjuvant activity of salidroside liposome. Here we reported the preparation, the effect on DCs in vitro and the immune response in vivo. The immunological adjuvant activity of salidroside liposome formulation was compared with that of salidroside and liposome. The result showed that salidroside liposome formulation not only could promote the maturation of DCs, the stimulation of DCs on MLR proliferation and the antigen presenting ability, but also induced the sustained cellular immune and humoral immune response. Overall, the results showed that salidroside liposome formulation had the potential to act as effective sustained release vaccine delivery systems. (C) 2013 Elsevier B.V. All rights reserved.

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