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The role of NADPH oxidase in taurine attenuation of Streptococcus uberis-induced mastitis in rats

文献类型： 外文期刊

作者： Miao, Jinfeng 1 ; Zhang, Jinqiu 2 ; Ma, Zili 1 ; Zheng, Liuhai 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China

2.Jiangsu Acad Agr Sci, Natl Res Ctr Vet Vaccine Engn & Technol China, Nanjing 210014, Jiangsu, Peoples R China

关键词： Streptococcus uberis;Mastitis;Taurine;p47phox;p22phox

期刊名称：INTERNATIONAL IMMUNOPHARMACOLOGY （ 影响因子：4.932； 五年影响因子：4.624 ）

ISSN： 1567-5769

年卷期： 2013 年 16 卷 4 期

页码：

收录情况： SCI

摘要： In order to evaluate the role of taurine on the oxidative stress mediated by NADPH oxidase in Streptococcus uberis-induced (S. uberis) mastitis, rats were administered daily (per os) 100 mg/kg of taurine (group TS) or an equal volume of physiological saline (group CS) from gestation day 14 until parturition. Seventy-two hours after parturition, approximately 100 cfu of S. uberis was infused into each of 2 mammary glands. Pretreatment with taurine significantly decreased mRNA and protein expression of p47phox and p22phox in mammary tissues. The total anti-oxidation capability (T-AOC) levels and superoxide dismutase (SOD) activities decreased, while rnalondialdehyde (MDA) levels increased both in mammary tissues and serum of rats with intramammary S. uberis infusion. Gavage administration of taurine moderated this change. Concentrations of interleukin-1 beta (IL-1 beta) and IL-6 in mammary glands decreased as a result of taurine administration. Significant differences (P < 0.05) were present at 48 and 72 h post S. uberis-infusion (PI) for IL-1 beta and 72 h PI for IL-6. Our data indicate that, in S. uberis-induced mastitis, taurine has the ability of regulating redox conditions which leads to the suppression of oxidative stress and secretion of proinflammatory cytokines. This phenomenon may be ascribed to taurines's ability to inhibit the expression of NADPH oxidase. (c) 2013 Elsevier B.V. All rights reserved.

  • 相关文献

[1]The effect of taurine on the toll-like receptors/nuclear factor kappa B (TLRs/NF-kappa B) signaling pathway in Streptococcus uberis-induced mastitis in rats. Miao, Jinfeng,Zheng, Liuhai,Ma, Zili,Zhu, Wei,Zou, Sixiang,Zhang, Jinqiu. 2011

[2]Taurine attenuates Streptococcus uberis-induced mastitis in rats by increasing T regulatory cells. Miao, Jinfeng,Zheng, Liuhai,Yu, Xiaoming,Zhu, Wei,Zou, Sixiang,Zhang, Jinqiu.

[3]The role of Ca2+ mediated signaling pathways on the effect of taurine against Streptococcus uberis infection. Dai, Bin,Liu, Ming,Zhang, Yuanshu,Xu, Yuanyuan,Miao, Jinfeng,Zhang, Jinqiu,Lu, Jinye,Yin, Yulong.

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