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Development of recombinant porcine parvovirus-like particles as an antigen carrier formed by the hybrid VP2 protein carrying immunoreactive epitope of porcine circovirus type 2

文献类型： 外文期刊

作者： Pan, Qunxing 1 ; He, Kongwang 1 ; Huang, Kehe 2 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing 210014, Jiangsu Prov, Peoples R China

2.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China

关键词： virus-like particles;hybrid;PCV2;PPV

期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）

ISSN： 0264-410X

年卷期： 2008 年 26 卷 17 期

页码：

收录情况： SCI

摘要： Virus-Like particles (VLPs) are non-repticative vectors for delivery of heterologous epitopes and induction of immune responses. In this study, a self-assembled porcine parvovirus (PPV) VP2 capsid protein [PPV:VLP-(PCV2)] carrying immunoreactive epitopes, residues 165-200 from the Porcine circovirus 2 (PCV2) virus nucleoprotein was constructed. Immunogenicity study was carried out with hybrid VLPs derived from HEK-293 cells infected with recombinant adenovirus vectors. To our knowledge, this study presents the first demonstration that hybrid non-repticative PPV VLPs carrying PCV2 immunoreactive epitopes can induce stronger antibody responses against PCV2 than recombinant adenovirus of PCV2 ORF2, in the absence of any adjuvant. The hybrid VLPs [PPV:VLP-(PCV2)] might be a promising candidate vaccine for better prevention of the diseases associated with PCV2 as well as with co-infection by PCV2 and PPV. (C) 2008 Elsevier Ltd. All rights reserved.

  • 相关文献

[1]Influence of minor displacements in loops of the porcine parvovirus VP2 capsid on virus-like particles assembly and the induction of antibody responses. Pan, Qunxing,He, Kongwang,Wang, Yongshan,Wang, Xiaoli,Ouyang, Wei.

[2]猪圆环病毒2型标签重组病毒构建和免疫试验. 华涛,唐波,常晨,刘国阳,张雪花,于漾,侯继波,张道华. 2018

[3]提高猪圆环病毒2型产量的方法比较. 华涛,张雪花,唐波,常晨,刘国阳,冯磊,吴培培,张道华,侯继波. 2015

[4]Development of real-time PCR assay for detection of porcine circovirus-like virus P1 in domestic pigs in China. He, Kong-wang,Lu, Cheng-ping,He, Kong-wang,Wen, Li-bin,Wang, Yong-shan. 2015

[5]Nitric oxide-generating compound GSNO suppresses porcine circovirus type 2 infection in vitro and in vivo. Liu, Chuanmin,Wen, Libin,Xiao, Qi,He, Kongwang,Liu, Chuanmin,Wen, Libin,Xiao, Qi,He, Kongwang,Liu, Chuanmin,Wen, Libin,Xiao, Qi,He, Kongwang,Liu, Chuanmin,Wen, Libin,Xiao, Qi,He, Kongwang. 2017

[6]Role of Chinese herbal medicinal ingredients in secretion of cytokines by PCV2-induced endothelial cells. Hu, Yiyi,He, Kongwang,Wang, Xiaomin. 2016

[7]Single Dose of Consensus Hemagglutinin-Based Virus-Like Particles Vaccine Protects Chickens against Divergent H5 Subtype Influenza Viruses. Wu, Peipei,Lu, Jihu,Zhang, Xuehua,Mei, Mei,Feng, Lei,Hou, Jibo,Tang, Yinghua,Wu, Peipei,Lu, Jihu,Zhang, Xuehua,Mei, Mei,Feng, Lei,Hou, Jibo,Tang, Yinghua,Wu, Peipei,Lu, Jihu,Zhang, Xuehua,Mei, Mei,Feng, Lei,Peng, Daxin,Hou, Jibo,Liu, Xiufan,Tang, Yinghua,Peng, Daxin,Liu, Xiufan,Kang, Sang-Moo. 2017

[8]Immunogenicity of different recombinant rabbit hemorrhagic disease virus-like particles carrying CD8+T cell epitope from chicken ovalbumin (OVA). Chen, Mengmeng,Song, Yanhua,Fan, Zhiyu,Hu, Bo,Xue, Jiabin,Wei, Houjun,Wang, Fang,Chen, Mengmeng,Jiang, Ping.

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