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Comparison of four infectious bursal disease viruses isolated from different bird species

文献类型： 外文期刊

作者： Wang, Y. S. 1 ; Wang, Z. C. 2 ; Tang, Y. D. 2 ; Shi, Z. L. 2 ; He, K. W. 3 ; Li, Y.; Hou, J. B.; Yao, H. C.; Fan, H 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing 210014, Jiangsu, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing 210014, Jiangsu, Peoples R China; Huadong Res Inst Med Bioeth, Ctr Dis Control & Prevent Nanjing Command, Nanjing, Peoples R China; Nanjing Agr Univ, Coll Vet Med, Dept Vet Microbiol & Immunol, Nanjing, Peoples R China

3.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing 210014, Jiangsu, Peoples R China; Huadong Res Inst Med Bioeth, Ctr Dis Control & Prevent Nanjing Command, Nanj

期刊名称：ARCHIVES OF VIROLOGY （ 影响因子：2.574； 五年影响因子：2.466 ）

ISSN： 0304-8608

年卷期： 2007 年 152 卷 10 期

页码：

收录情况： SCI

摘要： Four isolates of infectious bursal disease virus (IBDV), isolated from chicken, duck, goose and sparrow in Jiangsu province of China in 2002, were compared. The viruses were stable to the treatments of 60 degrees C for 1 h, pH 2.0 and lipid solvents. Their antigenic relatedness values (R) were from 0.76 to 0.78. Chickens infected with the chicken isolate showed severe clinical symptoms of IBD and the mortality rate was 33.3% (2/6). Chickens infected with the other three viruses survived but their bursas were damaged and the bursa/body-weight ratios were lower than those of the uninfected control (p < 0.01). The titers of anti-IBDV antibody in infected chicken sera reached up to 1600 by virus neutralization and 6400 by ELISA at 10 days post infection. The sequences of the variable region of VP2 were aligned and compared, showing nucleotide variations ranging from 1.5 to 6.7% and deduced aminoacid variations from 0.8 to 2.2%. All had the same heptapeptide, S-W-S-A-S-G-S, Asp279, and Ala284. The four viruses clustered on a phylogenetic tree and were distant from the STC strain. These findings suggested that different bird species naturally infected with IBDV could serve as carriers or reservoirs in IBDV transmission and might play a role in the emergence of variant IBDV.

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