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A Tiny RNA that Packs a Big Punch: The Critical Role of a Viral miR-155 Ortholog in Lymphomagenesis in Marek's Disease

文献类型： 外文期刊

作者： Zhuang, Guoqing 1 ; Sun, Aijun 1 ; Teng, Man 2 ; Luo, Jun 2 ;

作者机构： 1.Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Pathobiol, College Stn, TX 77843 USA

2.Henan Acad Agr Sci, Henan Prov Key Lab Anim Immunol, Key Lab Anim Immunol, Minist Agr, Zhengzhou, Peoples R China

3.Henan Univ Sci & Technol, Coll Anim Sci & Technol, Luoyang, Peoples R China

关键词： herpesvirus;Marek's disease virus;GaHV2;miR-155;miR-M4-5p;pathogenesis;tumorigenesis

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.64； 五年影响因子：6.32 ）

ISSN： 1664-302X

年卷期： 2017 年 8 卷

页码：

收录情况： SCI

摘要： MicroRNAs (miRNAs) are small non-coding RNAs that have been identified in animals, plants, and viruses. These small RNAs play important roles in post-transcriptional regulation of various cellular processes, including development, differentiation, and all aspects of cancer biology. Rapid-onset T-cell lymphoma of chickens, namely Marek's disease (MD), induced by Gallid alphaherpesvirus 2 (GaHV2), could provide an ideal natural animal model for herpesvirus-related cancer research. GaHV2 encodes 26 mature miRNAs derived from 14 precursors assembled in three distinct gene clusters in the viral genome. One of the most highly expressed GaHV2 miRNAs, miR-M4-5p, shows high sequence similarity to the cellular miR-155 and the miR-K12-11 encoded by Kaposi's sarcoma-associated herpesvirus, particularly in the miRNA "seed region." As with miR-K12-11, miR-M4-5p shares a common set of host and viral target genes with miR-155, suggesting that they may target the same regulatory cellular networks; however, differences in regulatory function between miR-155 and miR-M4-5p may distinguish non-viral and viral mediated tumorigenesis. In this review, we focus on the functions of miR-M4-5p as the viral ortholog of miR-155 to explore how the virus mimics a host pathway to benefit the viral life cycle and trigger virus-induced tumorigenesis.

  • 相关文献

[1]Putative roles as oncogene or tumour suppressor of the Mid-clustered microRNAs in Gallid alphaherpesvirus 2 (GaHV2) induced Marek's disease lymphomagenesis. Teng, Man,Wu, Zi-Xiang,Wu, Run,Teng, Man,Zhao, Pu,Dang, Lu,Li, Hui-Zhen,Ma, Sheng-Ming,Luo, Jun,Yu, Zu-Hua,Ma, Sheng-Ming,Luo, Jun,Zhuang, Guo-Qing,Cui, Zhi-Zhong,Zhang, Gai-Ping,Zhang, Gai-Ping.

[2]Marek's disease virus type 1 encoded analog of miR-155 promotes proliferation of chicken embryo fibroblast and DF-1 cells by targeting hnRNPAB. Dang, Lu,Zhou, En-Min,Zhang, Gai-Ping,Dang, Lu,Teng, Man,Li, Hui-Zhen,Ma, Sheng-Ming,Lu, Qing-Xia,Hao, Hui-Fang,Zhao, Dong,Luo, Jun,Li, Hui-Zhen,Zhang, Gai-Ping,Ma, Sheng-Ming,Luo, Jun,Zhang, Gai-Ping.

[3]Marek's disease virus-encoded microRNAs: genomics, expression and function. Luo Jun,Teng Man,Fan JianMing,Wang FangYu,Zhou Ling,Deng RuiGuang,Zhang GaiPing,Fan JianMing. 2010

[4]Virus-encoded miR-155 ortholog is an important potential regulator but not essential for the development of lymphomas induced by very virulent Marek's disease virus. Yu, Zu-Hua,Teng, Man,Yu, Le-Le,Hu, Bo,Zhang, Gai-Ping,Luo, Jun,Yu, Zu-Hua,Hu, Bo,Liu, Ju-Xiong,Zhang, Gai-Ping,Sun, Ai-Jun,Cui, Zhi-Zhong,Qu, Liang-Hu,Yu, Zu-Hua,Ding, Ke,Cheng, Xiang-Chao,Luo, Jun.

[5]马立克病病毒miR-M4-5p宿主靶基因cDNA文库的构建及鉴定. 薛正飞,滕蔓,李会珍,马圣明,宋利娜,张雅,罗俊,张改平. 2018

[6]Marek's disease virus-encoded analog of microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-beta signaling pathway. Chi, Jia-Qi,Yu, Zu-Hua,Chi, Jia-Qi,Teng, Man,Yu, Zu-Hua,Su, Jing-Wei,Zhao, Pu,Xing, Guang-Xu,Deng, Rui-Guang,Luo, Jun,Su, Jing-Wei,Zhao, Pu,Liang, Hong-De,Zhang, Gai-Ping,Qu, Liang-Hu,Zhang, Gai-Ping.

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