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Avian Influenza H5N6 Viruses Exhibit Differing Pathogenicities and Transmissibilities in Mammals

文献类型： 外文期刊

作者： Zhao, Zongzheng 1 ; Guo, Zhendong 1 ; Zhang, Chunmao 1 ; Liu, Lina 1 ; Chen, Ligong 2 ; Zhang, Cheng 3 ; Wang, Zhongyi 1 ;

作者机构： 1.Acad Mil Med Sci, Inst Mil Vet, 666 West Liuying Rd, Changchun 130122, Jilin, Peoples R China

2.Hebei Agr Univ, Coll Vet Med, 2596 Lucky South St, Baoding 071000, Hebei, Peoples R China

3.Hebei Agr Univ, Coll Vet Med, 2596 Lucky South St, Baoding 071000, Hebei, Peop

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2017 年 7 卷

页码：

收录情况： SCI

摘要： Since 2013, highly pathogenic avian influenza H5N6 viruses have emerged in poultry and caused sporadic infections in humans, increasing global concerns regarding their potential as human pandemic threats. Here, we characterized the receptor-binding specificities, pathogenicities and transmissibilities of three H5N6 viruses isolated from poultry in China. The surface genes hemagglutinin (HA) and neuraminidase (NA) were closely related to the human-originating strain A/Changsha/1/2014 (H5N6). Phylogenetic analyses showed that the HA genes were clustered in the 2.3.4.4 clade, and the NA genes were derived from H6N6 viruses. These H5N6 viruses bound both alpha-2,3-linked and alpha-2,6-linked sialic acid receptors, but they exhibited different pathogenicities in mice. In addition, one virus was fully infective and transmissible by direct contact in guinea pigs. These results highlight the importance of monitoring the continual adaptation of H5N6 viruses in poultry due to their potential threat to human health.

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