New Cytotoxic Alkylated Anthraquinone Analogues from a Soil Actinomycete Streptomyces sp WS-13394
文献类型： 外文期刊
作者： Wu, Zhao-Yuan 1 ; Fang, Wei 1 ; Shi, Li-Qiao 1 ; Wan, Zhong-Yi 1 ; Min, Yong 1 ; Wang, Kai-Mei 1 ;
作者机构： 1.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China
关键词： alkylated anthraquinone;Streptomyces sp WS-13394;actinomycete;cytotoxic
期刊名称：CHEMICAL & PHARMACEUTICAL BULLETIN （ 影响因子：1.645； 五年影响因子：1.613 ）
ISSN： 0009-2363
年卷期： 2014 年 62 卷 1 期
页码：
收录情况： SCI
摘要： Four new alkylated anthraquinone analogues (1-4) were isolated from a soil actimomycete Streptomyces sp. WS-13394. The structures of compounds 1-4 were elucidated to be 1,4,6-trihydroxy-8-alkylanthraquinones by means of spectroscopic methods, including UV, one dimensional (1D), 2D-NMR and MS spectrometry. All compounds showed activities against BGC-823 and MCF-7 with IC50 from 0.99 to 3.54 mu g/mL, while 2 exhibited cytotoxicity against HepG2, A875, BGC-823 and MCF-7 with IC50 2.29, 4.90, 0.99, and 1.66 mu g/mL, respectively.
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