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Synthesis of Novel Steroid Derivatives Derived from Dehydroepiandrosterone as Potential Anticancer Agents

文献类型: 外文期刊

作者: Ke, Shaoyong 1 ; Wei, Yanhong 2 ; Shi, Liqiao 1 ; Yang, Qingyu 1 ; Yang, Ziwen 1 ;

作者机构: 1.Hubei Acad Agr Sci, Natl Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China

2.Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China

关键词: Dehydroepiandrosterone;Analogues;Synthesis;Antitumor activity

期刊名称:ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY ( 影响因子:2.505; 五年影响因子:2.668 )

ISSN: 1871-5206

年卷期: 2013 年 13 卷 8 期

页码:

收录情况: SCI

摘要: A series of dehydroepiandrosterone derivatives containing dihydrazone unit was synthesized via a convenient condensation procedure, and which were evaluated for their potential anticancer activities. The preliminary assays indicated that some of the newly synthesized compounds exhibited good antitumor activities against human hepatocellular liver carcinoma (HepG2), heptoma (Huh-7), gastric cancer (BGC-823) and breast adenocarcinoma (MCF-7) cell lines compared with 5-fluorouracil (5-FU), which might be considered as promising lead scaffold for further design and synthesis of potential anticancer agents.

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