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Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum

文献类型： 外文期刊

作者： Huang, Sheng-Zhuo 1 ; Ma, Qing-Yun 1 ; Kong, Fan-Dong 1 ; Guo, Zhi-Kai 1 ; Cai, Cai-Hong 1 ; Hu, Li-Li 1 ; Zhou, Li-Ma 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Hainan, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop

关键词： Ganoderma calidophilum;Ganodermataceae;Lanostane triterpenoid;Cytotoxic activity

期刊名称：PHYTOCHEMISTRY （ 影响因子：4.072； 五年影响因子：4.132 ）

ISSN： 0031-9422

年卷期： 2017 年 143 卷

页码：

收录情况： SCI

摘要： To search for active anti-cancer constituents in the fruiting body of Ganoderma calidophilum, we have successfully isolated four previously undescribed spiro-lactone lanostane triterpenoids (spiroganocalitones A-D), two previously undescribed lanostanoids (ganodecalones A and B) together with twenty-three known ones. The structures of the six previously undescribed compounds were elucidated based on 1D, 2D-NMR, and HRMS analyses. Ganoderone A showed moderate cytotoxic activity against K562, BEL7402, and SGC790 cell lines with IC50 values of 7.62, 6.28, and 3.55 mu M, respectively. (C) 2017 Elsevier Ltd. All rights reserved.

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