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Angucyclines from an insect-derived actinobacterium Amycolatopsis sp HCa1 and their cytotoxic activity

文献类型： 外文期刊

作者： Guo, Zhi Kai 2 ; Liu, Shou Bai 2 ; Jiao, Rui Hua 1 ; Wang, Ting 1 ; Tan, Ren Xiang 1 ; Ge, Hui Ming 1 ;

作者机构： 1.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Inst Funct Biomol, Nanjing 210093, Jiangsu, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Peoples R China

关键词： Amycolatopsis;Pseudonocardiaceae;Angucycline;Cytotoxic effects

期刊名称：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS （ 影响因子：2.823； 五年影响因子：2.677 ）

ISSN： 0960-894X

年卷期： 2012 年 22 卷 24 期

页码：

收录情况： SCI

摘要： One new angucyclinone derivative, amycomycin A (1), and one new angucycline, amycomycin B (2), along with 5 known compounds (3-7), were isolated from an actinobacterium Amycolatopsis sp. HCa1 associated with the grasshopper, Oxya chinensis. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 1-7 were tested in vitro for their cytotoxic effects on five cell lines including human gastric adenocarcinoma cell line (BGC823), human hepatocarcinoma cell line (HepG2), human melanoma cell line (A375), human oral squamous carcinoma cell line (KB), and ghost cell line (Ghost-R5X4). Cell viability assays showed that compound 7 was active in four cell lines with IC50 values less than 18.0 mu M except in KB showing no activity up to 100 mu M. (C) 2012 Elsevier Ltd. All rights reserved.

  • 相关文献

[1]Actinotetraoses A-H: Tetrasaccharide Derivatives from a Grasshopper-Associated Amycolatopsis sp HCa1. Guo, Zhi Kai,Zhang, Gao Fei,Jiao, Rui Hua,Shen, Yan,Xu, Qiang,Tan, Ren Xiang,Ge, Hui Ming,Guo, Zhi Kai,Guo, Zhi Kai. 2012

[2]Actinotetraose L, a new tetrasaccharide derivative isolated from the mycelia of Amycolatopsis sp HCa1. Guo, Zhi-Kai,Yan, Wei,Tan, Ren-Xiang,Ge, Hui-Ming.

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