文献类型： 外文期刊
作者： Dong, Wen-Hua 1 ; Mei, Wen-Li 1 ; Zhao, You-Xing 1 ; Zeng, Yan-Bo 1 ; Zuo, Wen-Jian 1 ; Wang, Hui 2 ; Li, Xiao-Na; Dai 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Inst Trop Biosci & Biotechnol, Haikou Key Lab Res & Dev Trop Nat Prod, Haikou 571101, Hainan, Peoples R China
2.Chinese Acad Trop Agr Sci, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Inst Trop Biosci & Biotec
关键词： Antiaris toxicaria;Moraceae;cardenolides;SGC-7901;SMMC-7721
期刊名称：PLANTA MEDICA （ 影响因子：3.352； 五年影响因子：3.4 ）
ISSN： 0032-0943
年卷期： 2011 年 77 卷 15 期
页码：
收录情况： SCI
摘要： Bioassay-guided fractionation of the ethanolic extract from the seeds of Antiaris toxicaria led to the isolation of three new cardiac glycosides named toxicarioside J (1), toxicarioside K (2), and toxicarioside L (3), together with a known glucostrophalloside (4). The structures of the new compounds were elucidated by spectroscopic methods including HRESIMS, UV, IR, and 1D, 2D NMR techniques. The cytotoxic activities of these cardiac glycosides against human gastric (SGC-7901) and human hepatoma (SMMC-7721) cell lines were evaluated, and all of them exhibited significant cytotoxicity.
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