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Cytotoxic Cardenolide Glycosides from the Seeds of Antiaris toxicaria

文献类型： 外文期刊

作者： Dong, Wen-Hua 1 ; Mei, Wen-Li 1 ; Zhao, You-Xing 1 ; Zeng, Yan-Bo 1 ; Zuo, Wen-Jian 1 ; Wang, Hui 2 ; Li, Xiao-Na; Dai 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Inst Trop Biosci & Biotechnol, Haikou Key Lab Res & Dev Trop Nat Prod, Haikou 571101, Hainan, Peoples R China

2.Chinese Acad Trop Agr Sci, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Inst Trop Biosci & Biotec

关键词： Antiaris toxicaria;Moraceae;cardenolides;SGC-7901;SMMC-7721

期刊名称：PLANTA MEDICA （ 影响因子：3.352； 五年影响因子：3.4 ）

ISSN： 0032-0943

年卷期： 2011 年 77 卷 15 期

页码：

收录情况： SCI

摘要： Bioassay-guided fractionation of the ethanolic extract from the seeds of Antiaris toxicaria led to the isolation of three new cardiac glycosides named toxicarioside J (1), toxicarioside K (2), and toxicarioside L (3), together with a known glucostrophalloside (4). The structures of the new compounds were elucidated by spectroscopic methods including HRESIMS, UV, IR, and 1D, 2D NMR techniques. The cytotoxic activities of these cardiac glycosides against human gastric (SGC-7901) and human hepatoma (SMMC-7721) cell lines were evaluated, and all of them exhibited significant cytotoxicity.

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[1]A new cytotoxic cardenolide from the latex of Antiaris toxicaria. Gan, Yu Juan,Mei, Wen Li,Dai, Hao Fu,Zhao, You Xing. 2009

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[3]长春花4种提取物肝癌细胞毒活性的研究. 曾艳波,梅文莉,董文化,李小娜,戴好富. 2012

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[5]A new drimane sesquiterpenoid glycoside from the seeds of Antiaris toxicaria. Dong, Wen-Hua,Mei, Wen-Li,Zhao, You-Xing,Zeng, Yan-Bo,Wang, Hui,Dai, Hao-Fu,Dong, Wen-Hua,Mei, Wen-Li,Zhao, You-Xing,Zeng, Yan-Bo,Wang, Hui,Dai, Hao-Fu. 2011

[6]Study on the Chemical Constituents from the Latex of Antiaris toxicaria. Mei Wenli,Gan Yujuan,Que Dongmei,Li Xiaona,Dai Haofu. 2011

[7]Structure Elucidation of Flavonoids from Antiaris toxicaria Roots. Que Dongmei,Mei Wenli,Wu Jiao,Han Zhuang,Dai Haofu. 2009

[8]Two new cytotoxic cardenolides from the latex of Antiaris toxicaria. Dai, Hao-Fu,Gan, Yu-Juan,Que, Dong-Mei,Wu, Jiao,Mei, Wen-Li,Wen, Zhen-Chang. 2009

[9]A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria. Dai, Hao-Fu,Gan, Yu-Juan,Que, Dong-Mei,Wu, Jiao,Mei, Wen-Li,Wen, Zhen-Chang. 2009

[10]Two new strophanthidol cardenolides from the seeds of Antiaris toxicaria. Zuo, Wen-Jian,Dong, Wen-Hua,Zhao, You-Xing,Chen, Hui-Qin,Mei, Wen-Li,Dai, Hao-Fu,Jing-Chen.

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