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A new cytotoxic homoisoflavonoid from Dracaena cambodiana

文献类型: 外文期刊

作者: Liu, Jian 1 ; Mei, Wen-Li 1 ; Wu, Jiao 1 ; Zhao, You-Xing 2 ; Peng, Ming 1 ; Dai, Hao-Fu 1 ;

作者机构: 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou, Peoples R China

2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China

关键词: Dracaena cambodiana;Agavaceae;homoisoflavonoid;cytotoxicity;cambodianol

期刊名称:JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH ( 影响因子:1.569; 五年影响因子:1.598 )

ISSN: 1028-6020

年卷期: 2009 年 11 卷 2 期

页码:

收录情况: SCI

摘要: A new homoisoflavonoid, named cambodianol (1), together with the two known flavanes, (2S)-7,3'-dihydroxy-4'-methoxy-8-methylflavane (2) and (2R)-7,4'-dihydroxy-8-methylflavane (3), were isolated from the stems of Dracaena cambodiana. Their structures were determined based on HR-ESI-MS and spectroscopic techniques (UV, IR, 1D-, and 2D-NMR). Compound 1 exhibited significant cytotoxic activities against K562 and SGC-7901 with the IC50 values of 1.4 and 2.9g/ml, respectively.

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