Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation
文献类型： 外文期刊
作者： Ma, Jing 1 ; Huang, Cui 1 ; Ma, Kun 1 ; Wu, Yan-Ping 1 ; Li, Bai-Xiang 1 ; Sun, Yan 1 ;
作者机构： 1.Harbin Med Univ, Sch Publ Hlth, Dept Toxicol, 157 Baojian Rd, Harbin 150081, Heilongjiang, Peoples R China
2.Heilongjiang Acad Agr Sci, Wuchang Rice Res Inst, Harbin 150229, Heilongjiang, Peoples R China
关键词： Parkinson's disease;paraquat;maneb;neurotoxicity;Wnt1;Wnt5a
期刊名称：MOLECULAR MEDICINE REPORTS （ 影响因子：2.952； 五年影响因子：2.754 ）
ISSN： 1791-2997
年卷期： 2017 年 16 卷 6 期
页码：
收录情况： SCI
摘要： Paraquat (PQ) and maneb (MB) are widely used herbicides. Wingless (Wnt) proteins serve a role in the development and differentiation of dopaminergic neurons. Previous studies demonstrated that combined exposure to PQ and MB damages dopaminergic neurons in the midbrain. Effects of PQ and MB exposure on midbrain Wnt proteins have also been previously reported. In the present study, from the 5th day of gestation to weaning of the offspring, pregnant Sprague-Dawley rats were administrated saline, or PQ and MB at two different doses: high, 15 mg/kg body weight PQ + 45 mg/kg body weight MB; or low, 10 mg/kg body weight PQ + 30 mg/kg body weight MB. Dopamine content in the striatum was examined by high performance liquid chromatography with a fluorescence detector and mRNA and protein expression of Wnt1, Wnt5a, nuclear receptor related factor 1 (Nurr1) and tyrosine hydroxylase (TH) in the midbrain was examined by reverse transcription-quantitative polymerase chain reaction and western blotting. Combined exposure to PQ and MB during development decreased mRNA and protein expression of Wnt1, TH and Nurr1 and increased expression of Wnt5a in the offspring.
- 相关文献
作者其他论文 更多>>
-
Genome-Wide Identification and Expression Analysis Under Abiotic Stress of the Lipoxygenase Gene Family in Maize (Zea mays)
作者：Li, Sinan;Hou, Shuai;Sun, Yuanqing;Sun, Minghao;Sun, Yan;Li, Xin;Li, Yunlong;Wang, Luyao;Cai, Quan;Guo, Baitao;Zhang, Jianguo
关键词：maize; LOX; abiotic stress; gene family; expression analysis
-
Integrating Genetic Diversity and Agronomic Innovations for Climate-Resilient Maize Systems
作者：Li, Xin;Li, Yunlong;Sun, Yan;Li, Sinan;Cai, Quan;Li, Shujun;Sun, Minghao;Yu, Tao;Meng, Xianglong;Zhang, Jianguo
关键词：maize; climate resilience; climatic change; genomic selection; multiomics; speed breeding; gene editing
-
Functional Analysis of Zinc Finger Protein Transcription Factor ZmZFP69 Under Low-Temperature Stress at Maize Seedling Stage
作者：Li, Si-Nan;Sun, Yan;Li, Yun-Long;Sun, Ming-Hao;Li, Shu-Jun;Yin, Yue;Yu, Tao;Li, Xin;Cai, Quan;Zhang, Jian-Guo
关键词：zinc finger protein;
ZmZFP69 ; maize; low-temperature stress -
Two genetically modified insect-resistant maize events reduced fumonisin pollution under the stress of Lepidoptera in China
作者：Zhao, Lin;Lan, Jing;Zhang, Xiaolei;Huang, Cui;Ma, Wenqiong;Du, Yingqiu;Liu, Baohai;Zhao, Lin;Lan, Jing;Zhang, Xiaolei;Huang, Cui;Ma, Wenqiong;Du, Yingqiu;Liu, Baohai;Zhang, Yun;Zhao, Haiming
关键词：
Bt maize; fumonisin; lepidopteran insect; transgenic events -
The EIN3 transcription factor GmEIL1 improves soybean resistance to Phytophthora sojae
作者：Chen, Xi;Sun, Yan;Yang, Yu;Zhao, Yuxin;Zhang, Chuanzhong;Fang, Xin;Gao, Hong;Zhao, Ming;He, Shengfu;Song, Bo;Liu, Shanshan;Xu, Pengfei;Zhang, Shuzhen;Chen, Xi;Wu, Junjiang;Zhang, Shuzhen;Xu, Pengfei;Zhang, Shuzhen;Wu, Junjiang
关键词：EIN3-binding sequence; ethylene; GmEIL1; Phytophthora root rot of soybean
-
Genetic Analysis of Adaptive Traits in Spring Wheat in Northeast China
作者：Zhang, Hongji;Liu, Wenlin;Sun, Yan;Tang, Jingquan;Yang, Shuping;Wang, Xiangyu;Li, Yuyao;Che, Jingyu;Zhang, Rui
关键词：adaptive traits; association analysis; candidate gene; marker-assisted selection; Triticum aestivum L.
-
The MYB Transcription Factor GmMYB78 Negatively Regulates Phytophthora sojae Resistance in Soybean
作者：Gao, Hong;Ma, Jia;Zhao, Yuxin;Zhang, Chuanzhong;Zhao, Ming;He, Shengfu;Sun, Yan;Fang, Xin;Chen, Xiaoyu;Ma, Kexin;Pang, Yanjie;Gu, Yachang;Dongye, Yaqun;Xu, Pengfei;Zhang, Shuzhen;Wu, Junjiang
关键词：GmMYB78; soybean; Phytophthora sojae; jasmonic acid; GmbHLH122; GmbZIP25
