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Lanostane triterpenoids from mycelia-associated Ganoderma sinense and their anti-inflammatory activity

文献类型： 外文期刊

作者： Teng, Liming 1 ; Wang, Chan 2 ; Cui, Baokai 1 ; Zhang, Jingsong 2 ; Zhou, Shuai 2 ; Pan, Xinhua 4 ; Pan, Feng 4 ; Dai, Yucheng 1 ; Feng, Na 2 ;

作者机构： 1.Beijing Forestry Univ, Sch Ecol & Nat Conservat, Beijing 100083, Peoples R China

2.Shanghai Acad Agr Sci, Inst Edible Fungi, Shanghai 201403, Peoples R China

3.East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China

4.Jiangxi Xiankelai Biotechnol Co Ltd, Jiujiang 332000, Peoples R China

5.Natl Engn Res Ctr Edible Fungi, Shanghai 201403, Peoples R China

关键词： Ganoderma sinense; Ganodermataceae; Static fermentation; Triterpenoids; Anti-inflammatory activity

期刊名称：PHYTOCHEMISTRY （ 影响因子：3.8； 五年影响因子：4.0 ）

ISSN： 0031-9422

年卷期： 2023 年 215 卷

页码：

收录情况： SCI

摘要： Seven previously undescribed lanostane triterpenoids, ganoderic acid M1 (1), M2 (2), M3 (3), M4 (4), M5 (5), M6 (6), and M7 (7), together with eight known compounds, were isolated from mycelia of the basidiomycete Ganoderma sinense (Ganodermataceae). The structures of all compounds were elucidated by spectroscopic analysis. The possible biosynthetic pathway of these fifteen triterpenoids was proposed. Some of the compounds were evaluated for their anti-inflammatory activity by measuring the production of nitric oxide (NO), TNF-alpha, and IL-6 in RAW264.7 macrophage cells induced by lipopolysaccharide. Lanosta-7,9(11),24-trien-3 beta,15 alpha,22 beta-triacetoxy-26-oic acid (14) exhibited the strongest inhibition of NO production with an IC50 of 0.6 +/- 0.1 mu M and completely inhibited the secretion of TNF-alpha and IL-6 at 10 mu M. The structure-activity relationship of the antiinflammatory activity is discussed.

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