您好，欢迎访问广东省农业科学院 机构知识库！
广东省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Modulatory effect of thymol on the immune response and susceptibility to Aeromonas hydrophila infection in Nile tilapia fish exposed to zinc oxide nanoparticles

文献类型： 外文期刊

作者： Khalil, Samah R. 1 ; Zheng, Chuntian 2 ; Abou-Zeid, Shimaa M. 3 ; Farag, Mayada R. 1 ; Elsabbagh, Hesham S. 3 ; Siddique, Mouhamed S. 3 ; Azzam, Mahmoud M. 4 ; Di Cerbo, Alessandro 5 ; Elkhadrawey, Basma A. 3 ;

作者机构： 1.Zagazig Univ, Fac Vet Med, Forens Med & Toxicol Dept, Zagazig 44519, Egypt

2.Guangdong Acad Agr Sci, Inst Anim Sci, Key Lab Anim Nutr & Feed Sci South China, Minist Agr,State Key Lab Livestock & Poultry Breed, Guangzhou 510640, Peoples R China

3.Univ Sadat City, Fac Vet Med, Forens Med & Toxicol Dept, Sadat 32897, Egypt

4.King Saud Univ, Dept Anim Prod Coll Food & Agr Sci, Riyadh 11451, Saudi Arabia

5.Univ Camerino, Sch Biosci & Vet Med, Matelica, Italy

关键词： Oreochromis niloticus; Zinc oxide nanoparticles; Thymol; Immunity

期刊名称：AQUATIC TOXICOLOGY （ 影响因子：4.5； 五年影响因子：5.2 ）

ISSN： 0166-445X

年卷期： 2023 年 259 卷

页码：

收录情况： SCI

摘要： Zinc oxide nanoparticles (ZnO-NPs) have many exciting properties that make their use in a continuous increase in various biomedical, industrial, and agricultural applications. This is associated with accumulation in the aquatic ecosystems and fish exposure with consequent deleterious effects. To determine the potential of thymol to counteract the immunotoxic effects of ZnO-NPs, Oreochromis niloticus was exposed to ZnO-NPs (1/5 LC50 =1.14 mg/L, for 28 days) with or without feeding a thymol-incorporated diet (1 or 2 g/kg diet). Our data demonstrated a reduction of aquaria water quality, leukopenia, and lymphopenia with a decrease in serum total protein, albumin, and globulin levels in exposed fish. At the same time, the stress indices (cortisol and glucose) were elevated in response to ZnO-NPs exposure. The exposed fish also revealed a decline in serum immunoglobulins, nitric oxide, and the activities of lysozyme and myeloperoxidase, in addition to reduced resistance to the Aeromonas hydrophila challenge. The RT-PCR analysis showed downregulation of antioxidant (SOD) superoxide dismutase and (CAT) catalase gene expression in the liver tissue with overexpression of the immune-related genes (TNF-alpha and IL-1 beta). Importantly, we found that thymol markedly protected against ZnO-NPs-induced immunotoxicity in fish co-supplemented with thymol (1 or 2 g/kg diet) in a dose-dependent manner. Our data confirm the immunoprotective and antibacterial effects of thymol in ZnO-NPs exposed fish, supporting the potential utility of thymol as a possible immunostimulant agent.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：广东省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台