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Plasma and tissue kinetics of enrofloxacin and its metabolite, ciprofloxacin, in yellow catfish (Pelteobagrus fulvidraco) after a single oral administration at different temperatures

文献类型： 外文期刊

作者： Xu, Ning 1 ; Sun, Weiyu 1 ; Zhang, Huan 1 ; Liu, Yongtao 1 ; Dong, Jing 1 ; Zhou, Shun 1 ; Yang, Yibin 1 ; Yang, Qiuhong 1 ; Ai, Xiaohui 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China

2.Hu Bei Prov Engn & Technol Res Ctr Aquat Prod Qual, Wuhan 430223, Peoples R China

3.Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Peoples R China

4.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, 8 Wuda Pk Rd 1, Wuhan 430223, Hubei, Peoples R China

关键词： Pharmacokinetics; Enrofloxacin; Ciprofloxacin; Yellow catfish; Different temperatures

期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY （ 影响因子：3.9； 五年影响因子：3.8 ）

ISSN： 1532-0456

年卷期： 2023 年 266 卷

页码：

收录情况： SCI

摘要： The objective of this study was to examine the pharmacokinetic (PK) properties of enrofloxacin (EF) and its metabolite, ciprofloxacin (CF), in yellow catfish (Pelteobagrus fulvidraco) after a single oral dose of EF at 20 mg/ kg at 20, 25, and 30 degrees C. Samples were collected at pre-designed time points and determined by high-performance liquid chromatography with a fluorescent detector. Results showed that most concentrations of EF and CF in plasma and tissues at the same time point at different temperatures were statistically significant. With the increase in temperature, the terminal half-life (T-1/2 lambda z) of EF and CF was first reduced from 20 to 25 degrees C but elevated from 25 to 30 degrees C in plasma, muscle + skin, gill, liver, and kidney, respectively. The area under the plasma concentration-time curves (AUC(last)) of EF were all decreased in plasma, muscle + skin, and gill except for that of EF in the liver and kidney. However, the AUC(last) and the apparent metabolic rate of CF were exhibited first elevated and then decreased trend. The apparent volume of distribution (Vz_F) of EF was first reduced from 20 to 25 degrees C but increased at 30 degrees C. The apparent total body clearance (CL_F) of EF was increased from 0.15 to 0.32 L/ h center dot kg with the temperature elevation. These indicated that increased temperature markedly affected the PKs of EF and CF in yellow catfish. Through in-depth analysis, the EF dosage of 20 mg/kg is appropriate to use in yellow catfish at 20 and 25 degrees C but 30 degrees C.

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