文献类型： 会议论文

第一作者： Rikke Buhl

作者： Rikke Buhl ¹ ; Julie Liebmann ¹ ; DagmarTrachsel ¹ ; Dirk Lebelt ² ; Diana Stucke ² ;

作者机构： 1.University of Copenhagen, Taastrup, Denmark

2.Pferdeklinik Havelland, Beetzsee, Germany

会议名称： Conference of the American College of Veterinary Internal Medicine

主办单位：

页码： 876-

摘要： Preliminary data from horses castrated under general anesthesia.Long-QT Syndrome (LOTS) is characterized by a delayed repolarization of cardiac cells resulting in prolonged action potentials and QT intervals on surface ECG. In humans it is associated with the predisposition to develop severe ventricular tachyarrhythmia, which can progress to sudden death. Altered function of K+ channels either due to mutations (inherited form of LQTS) or due to interaction with drugs affecting the function of K+ channels (acquired form of LQTS) are known in humans and dogs. LQTS hasnot yet been described in horses and the effect of hormones and various drugs on the duration of QT interval has only been scarcely described in this species. However, functional similarities between equine and human K+ channels allow the hypothesis that LQTS might also be present in horses. The purpose of this study was to assess the effect of withdrawal of androgens on cardiac repolarization by measuring the QT interval before and after castration. Further, as the same medication and anesthetic protocol was applied on each horse; we also studied the effect of drug combinations on the QT- interval.

分类号： S85-532