Insights into a functional synthetic plant genome

文献类型： 外文期刊

第一作者： Du, Fei

作者： Du, Fei;Du, Fei;Dai, Junbiao;Dai, Junbiao;Jiao, Yuling;Jiao, Yuling;Jiao, Yuling

作者机构：

关键词： chromosome replacement; epigenetic modification; Physcomitrium patens; synthetic genomics; transposable element

期刊名称：NEW PHYTOLOGIST （ 影响因子：8.3； 五年影响因子：10.2 ）

ISSN： 0028-646X

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Synthetic genomics involves the design, assembly, and transfer of artificially synthesized DNA fragments into target hosts to replace the native genome and construct viable forms of life. With advances in DNA synthesis and assembly techniques, the application of synthetic genomics in viruses, bacteria, and yeast has improved our knowledge of genome organization and function. Multicellular eukaryotic organisms are characterized by larger genomes, more complex epigenetic regulation, and widespread transposable elements, making genome synthesis challenging. Recently, the first synthetic multicellular eukaryotic organism was generated in the model plant Physcomitrium patens with a partially synthetic chromosome arm. Here, we introduce the design and assembly principles of moss genome synthesis. We also discuss the remaining technical barriers in the application of synthetic genomics in seed plants.

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