Expression profiles of host miRNAs and circRNAs and ceRNA network during Toxoplasma gondii lytic cycle
文献类型： 外文期刊
第一作者： Wang, Sha-Sha
作者： Wang, Sha-Sha;Wang, Xiangwei;He, Jun-Jun;Zhu, Xing-Quan;Zheng, Wen-Bin;Zhu, Xing-Quan;Elsheikha, Hany M.;Zhou, Chun-Xue
作者机构： Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Anim Dis Control & Prevent, Lanzhou Univ,Coll Vet Med, Lanzhou 730000, Gansu, Peoples R China;Yunnan Agr Univ, Coll Vet Med, Key Lab Vet Publ Hlth Higher Educ Yunnan Prov, Kunming 650500, Yunnan, Peoples R China;Shanxi Agr Univ, Coll Vet Med, Taigu 030801, Peoples R China;Univ Nottingham, Fac Med & Hlth Sci, Sch Vet Med & Sci, Sutton Bonington Campus, Loughborough LE12 5RD, England;Shandong Univ, Cheeloo Coll Med, Sch Basic Med Sci, Dept Pathogen Biol, Jinan 250100, Shandong, Peoples R China
关键词： Toxoplasma gondii; RNA-seq; circRNA; miRNA; Immune response; Host-pathogen interaction
期刊名称：PARASITOLOGY RESEARCH （ 2022影响因子：2.0； 五年影响因子：2.0 ）
ISSN： 0932-0113
年卷期： 2024 年 123 卷 2 期
收录情况： SCI
摘要： Toxoplasma gondii is an opportunistic protozoan parasite that is highly prevalent in the human population and can lead to adverse health consequences in immunocompromised patients and pregnant women. Noncoding RNAs, such as microRNAs (miRNAs) and circular RNAs (circRNAs), play important regulatory roles in the pathogenesis of many infections. However, the differentially expressed (DE) miRNAs and circRNAs implicated in the host cell response during the lytic cycle of T. gondii are unknown. In this study, we profiled the expression of miRNAs and circRNAs in human foreskin fibroblasts (HFFs) at different time points after T. gondii infection using RNA sequencing (RNA-seq). We identified a total of 7, 7, 27, 45, 70, 148, 203, and 217 DEmiRNAs and 276, 355, 782, 1863, 1738, 6336, 1229, and 1680 DEcircRNAs at 1.5, 3, 6, 9, 12, 24, 36, and 48 h post infection (hpi), respectively. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses revealed that the DE transcripts were enriched in immune response, apoptosis, signal transduction, and metabolism-related pathways. These findings provide new insight into the involvement of miRNAs and circRNAs in the host response to T. gondii infection.
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