Expression profiles of host miRNAs and circRNAs and ceRNA network during Toxoplasma gondii lytic cycle

文献类型： 外文期刊

第一作者： Wang, Sha-Sha

作者： Wang, Sha-Sha;Wang, Xiangwei;He, Jun-Jun;Zhu, Xing-Quan;Zheng, Wen-Bin;Zhu, Xing-Quan;Elsheikha, Hany M.;Zhou, Chun-Xue

作者机构：

关键词： Toxoplasma gondii; RNA-seq; circRNA; miRNA; Immune response; Host-pathogen interaction

期刊名称：PARASITOLOGY RESEARCH （ 影响因子：2.0； 五年影响因子：2.0 ）

ISSN： 0932-0113

年卷期： 2024 年 123 卷 2 期

页码：

收录情况： SCI

摘要： Toxoplasma gondii is an opportunistic protozoan parasite that is highly prevalent in the human population and can lead to adverse health consequences in immunocompromised patients and pregnant women. Noncoding RNAs, such as microRNAs (miRNAs) and circular RNAs (circRNAs), play important regulatory roles in the pathogenesis of many infections. However, the differentially expressed (DE) miRNAs and circRNAs implicated in the host cell response during the lytic cycle of T. gondii are unknown. In this study, we profiled the expression of miRNAs and circRNAs in human foreskin fibroblasts (HFFs) at different time points after T. gondii infection using RNA sequencing (RNA-seq). We identified a total of 7, 7, 27, 45, 70, 148, 203, and 217 DEmiRNAs and 276, 355, 782, 1863, 1738, 6336, 1229, and 1680 DEcircRNAs at 1.5, 3, 6, 9, 12, 24, 36, and 48 h post infection (hpi), respectively. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses revealed that the DE transcripts were enriched in immune response, apoptosis, signal transduction, and metabolism-related pathways. These findings provide new insight into the involvement of miRNAs and circRNAs in the host response to T. gondii infection.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序