Dynamic lipid profile of hyperlipidemia mice

文献类型： 外文期刊

第一作者： Chen, Yu-Lian

作者： Chen, Yu-Lian;Hu, Zhi-Xiong;Liu, Xiao-Shan;Liu, Zhiguo;Zhao, Xiu-Ju;Zhao, Xiu-Ju;Zhang, Wei-Nong;Xiao, Chuan-Hao

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关键词： Hyperlipidemia;Biomarkers of serum fatty acids;GC–MS

期刊名称：JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES （ 影响因子：3.205； 五年影响因子：3.068 ）

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收录情况： SCI

摘要： Highlights ? Hyperlipidemia mice had higher levels of ALT, GLC, TG and CHO. ? Hyperlipidemia mice had higher levels of C18:1 and lower C16:1 and C22:6. ? Hyperlipidemia mice had higher monounsaturated unsaturated degrees and lower polyunsaturated ones. Abstract Biomarkers of serum fatty acids in hyperlipidemia need to be elucidated. 90 SPF KM male mice were randomly divided into 18 groups (n=5/group), control groups, and high fat diet (HFD) groups at 9 time points. On day 7, 10, 15, 18, 21, 24, 28, 31, and 35, the mice were sacrificed; blood was collected into tubes from the eyes, serum samples for clinical biochemistry assays and gas chromatography–mass spectroscopy were attained after centrifugation, and the contents of serum fatty acids were detected with GC–MS. Sections of livers were taken and stored in formalin solution for histological assessments. No species differences existed in all these groups. The contents of C16:1, C18:1, C22:6 were significantly different between HFD groups and the corresponding controls; meanwhile, the proportion of fatty acids, especially the monounsaturated degree, the polyunsaturated degree, changed significantly and regularly (P< 0.05). Thus the three unsaturated fatty acids C16:1, C18:1, C22:6 and the monounsaturated/polyunsaturated unsaturated degrees may be as potential biomarkers of hyperlipidemia. ]]>

分类号： Q503

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