Homoerythrina-type alkaloids with neuroprotective activity from the branches of Cephalotaxus hainanensis Li
文献类型： 外文期刊
第一作者： Yan, Hao
作者： Yan, Hao;Zhou, Shuang-Qing;Yan, Hao;Wang, Hao;Chen, Peng-Wei;Yang, Li;Chen, Hui -Qin;Wu, Fei;Wang, Pei;Dai, Hao-Fu;Mei, Wen-Li;Huang, Xiao-Long
作者机构：
关键词： Cephalotaxus hainanensis Li; Homoerythrina-type alkaloid; Neuroprotective activity
期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.7； 五年影响因子：1.8 ）
ISSN： 1874-3900
年卷期： 2024 年 59 卷
页码：
收录情况： SCI
摘要： Lucidinine 13-N-oxide (1), one previously unreported homoerythrina N-oxide type alkaloid, and three known homoerythrina-type alkaloids (2-4) were isolated and elucidated from Cephalotaxus hainanensis Li. The structure of 1 were elucidated by extensive analysis of HRESIMS, 1D and 2D NMR data. The structures of three known alkaloids were elucidated by comparison with known compounds. The absolute configuration of 1 was estab-lished on the basis of experimental and computed ECD. All compounds was evaluated for neuroprotective ac-tivity against H2O2-induced apoptosis in human neuroblastoma SH-SY5Y cells. Lucidinine 13-N-oxide (1) significantly improved cell vitality of SH-SY5Y cells to 82.90 +/- 2.14% at concentration of 80 mu M.
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