Diversity of TNF-alpha region in Chinese domestic goats

文献类型： 外文期刊

第一作者： E, G. X.

作者： E, G. X.;Na, R. S.;Zhao, Y. J.;Huang, Y. F.;Ma, Y. H.

作者机构：

关键词： Chinese indigenous goat;Immunological diversity;Major histocompatibility complex class III;Tumor necrosis factor-alpha

期刊名称：GENETICS AND MOLECULAR RESEARCH （ 影响因子：0.764； 五年影响因子：0.912 ）

ISSN： 1676-5680

年卷期： 2015 年 14 卷 2 期

页码：

收录情况： SCI

摘要： Tumor necrosis factor-alpha is a cytokine with a wide range of effects on both lymphoid and non-lymphoid cells. In this study, we identified polymorphisms in major histocompatibility complex class III gene in the 4th exon and the 3' untranslated region of tumor necrosis factor-alpha to evaluate the immunogenetic diversity of Chinese south indigenous goat. Three single-nucleotide polymorphisms were identified and showed similar frequencies in different except MI loci. These data suggest that the high immunodiversity of the tumor necrosis factor-alpha region within these breeds can be used for strengthening variety improvement and promoting animal husbandry development in Chinese indigenous goats.

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