p-Terphenyl and Diterpenoid Metabolites from Endophytic Aspergillus sp YXf3

文献类型： 外文期刊

第一作者： Guo, Zhi Kai

作者： Guo, Zhi Kai;Yan, Tong;Guo, Ye;Song, Yong Chun;Jiao, Rui Hua;Tan, Ren Xiang;Ge, Hui Ming;Guo, Zhi Kai;Guo, Zhi Kai

作者机构：

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）

ISSN： 0163-3864

年卷期： 2012 年 75 卷 1 期

页码：

收录情况： SCI

摘要： Six new p-terphenyl derivatives, named 4"-deoxy-3-hydroxyterphenyllin (1), 4"-deoxy-5'-desmethylterphenyllin (2), 5'-desmethylterphenyllin (3), 4"-deoxycandidusin A (4), 4,5-dimethoxycandidusin A (5), and terphenolide (6), four new diterpenoids with norcleistanthane (aspergiloid A (12) and aspergiloid B (13)), cleistanthane (aspergiloid C (14)), and isopimarane (aspergiloid D (15)) type skeletons, and five known p-terphenyl compounds (7-11) were isolated from the fermentation broth of the plant endophytic fungus Aspergillus sp. Their structures were elucidated on the basis of detailed spectroscopic analysis and by comparison of their NMR data with those reported in the literature. Compounds 4, 6, 7, and 9 displayed moderate neuraminidase inhibitory activity with IC50 values ranging from 4.34 to 9.17 mu M.

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