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Macrophage-inspired magnetic silk fibroin porous microcarriers with exosome enrichment capability for bone repair

文献类型： 外文期刊

作者： Yang, Lei 1 ; Li, Wenzhao 3 ; Shang, Luoran 1 ; Zhao, Yuanjin 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Sericulture & Tea, Hangzhou 310021, Peoples R China

2.Southeast Univ, Nanjing Drum Tower Hosp, Sch Biol Sci & Med Engn, Dept Rheumatol & Immunol, Nanjing 210096, Peoples R China

3.Univ Chinese Acad Sci, Wenzhou Inst, Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Wenzhou 325001, Peoples R China

4.Fudan Univ, Zhongshan Xuhui Hosp, Shanghai Key Lab Med Epigenet, Minist Educ,Inst Biomed Sci,Int Colab Med Epigenet, Zhongshan, Shanghai, Peoples R China

关键词： Microcarrier; Exosome; Silk fibroin; Microfluidics; Bone repair

期刊名称：CHEMICAL ENGINEERING JOURNAL （ 影响因子：13.2； 五年影响因子：13.5 ）

ISSN： 1385-8947

年卷期： 2025 年 520 卷

页码：

收录情况： SCI

摘要： Bone defect remains a major challenge for clinicians. Exosome (Exo) therapy is a promising approach for bone repair. The current trend of Exo therapy is to develop multifunctional Exo delivery microcarriers to promote bone repair. Here, inspired by macrophage phagocytosis, magnetic silk fibroin porous microcarrier (MS) with Exo enrichment ability is developed via microfluidic technology for bone repair. Benefiting from the good droplet manipulation ability of microfluidic technology, the generated MS have good monodispersity and spherical morphology. With the assist of liquid nitrogen pre-freezing and ultraviolet (UV) crosslinking, the produced MS showed porous structure. Additionally, the addition of Fe3O4@MgSiO3 nanoparticle and the porous structure endowed the MS with good magnetic properties and satisfactory Exo capture capability after antibody modification. Moreover, the released Exo and microelement of Fe3O4@MgSiO3 from MS can effectively improve bone repair via angiogenesis and osteogenesis. The cell and animal experiments demonstrated that this kind of MS microcarriers have good biocompatibility, Exo enrichment ability and bone repair effect. These characteristics indicate that the designed MS is an effective carrier for Exo enrichment and delivery, and is expected to be a viable option for clinically relevant diseases therapy.

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