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Harnessing Biomaterials for Gene Therapy in Autoimmune Disease

文献类型： 外文期刊

作者： Huang, Wuxinrui 1 ; Lu, Juan 2 ; Xue, Zengqi 3 ; Tang, Beikang 2 ; Tian, Jing 2 ; Yang, Lei 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Sericulture & Tea, Hangzhou 310021, Peoples R China

2.Cent South Univ, Xiangya Hosp 2, Dept Rheumatol & Immunol, Changsha 410011, Peoples R China

3.Wenzhou Med Univ, Affiliated Hosp 3, Wenzhou 325200, Peoples R China

关键词： autoimmune disease; biomaterial; gene therapy

期刊名称：ADVANCED HEALTHCARE MATERIALS （ 影响因子：9.6； 五年影响因子：10.8 ）

ISSN： 2192-2640

年卷期： 2025 年

页码：

收录情况： SCI

摘要： The integration of biomaterials and gene therapy heralds a transformative approach for treating autoimmune diseases, which are characterized by immune dysregulation and chronic inflammation. Conventional therapies often suffer from systemic toxicity and nonspecific immunosuppression, highlighting the need for precision medicine strategies. This review highlights recent breakthroughs in biomaterial-assisted delivery of gene therapy tools, such as small interfering RNA (siRNA), messenger RNA (mRNA), and clustered regularly interspaced short palindromic repeats-CRISPR-associated 9 (CRISPR-Cas9). Advanced biomaterials, including lipid nanoparticles, polymeric micelles, inorganic nanoparticles (such as gold [Au] and graphene oxide [GO]), and extracellular vesicles (EVs), have been engineered to overcome key challenges, such as low targeting efficiency, enzymatic degradation, and off-target effects. Functionalized systems that leverage pH-, reactive oxygen species (ROS)-, or enzyme-responsive mechanisms enable spatiotemporally controlled release, thereby reducing off-target exposure and systemic toxicity, for example, by confining TNF-alpha siRNA release to inflamed joints in rheumatoid arthritis (RA). In contrast, ligand/receptor-mediated targeting (such as folate and CD44) enhances tissue specificity. This review highlights the pivotal role of biomaterials in improving the clinical translation of gene therapy, providing a roadmap for next-generation treatments that prioritize precision, durability, and minimal systemic effects.

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