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Application of Gene Editing Technology in Resistance Breeding of Livestock

文献类型： 外文期刊

作者： Wang, Sutian 1 ; Qu, Zixiao 1 ; Huang, Qiuyan 1 ; Zhang, Jianfeng 2 ; Lin, Sen 3 ; Yang, Yecheng 1 ; Meng, Fanming 1 ; Li, Jianhao 1 ; Zhang, Kunli 2 ;

作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, State Key Lab Livestock & Poultry Breeding, Guangdong Key Lab Anim Breeding & Nutr, Guangzhou 510640, Peoples R China

2.Guangdong Acad Agr Sci, Inst Anim Hlth, Guangdong Prov Key Lab Livestock Dis Prevent Guan, Guangzhou 510640, Peoples R China

3.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Guangzhou 510610, Peoples R China

4.Guangdong Lab Lingnan Modern Agr, Maoming Branch, Maoming 525100, Peoples R China

关键词： genome engineering; livestock breeding; pigs; cattle; sheep

期刊名称：LIFE-BASEL （ 影响因子：3.251； ）

ISSN：

年卷期： 2022 年 12 卷 7 期

页码：

收录情况： SCI

摘要： As a new genetic engineering technology, gene editing can precisely modify the specific gene sequence of the organism's genome. In the last 10 years, with the rapid development of gene editing technology, zinc-finger nucleases (ZFNs), transcription activator-like endonucleases (TALENs), and CRISPR/Cas9 systems have been applied to modify endogenous genes in organisms accurately. Now, gene editing technology has been used in mice, zebrafish, pigs, cattle, goats, sheep, rabbits, monkeys, and other species. Breeding for disease-resistance in agricultural animals tends to be a difficult task for traditional breeding, but gene editing technology has made this easier. In this work, we overview the development and application of gene editing technology in the resistance breeding of livestock. Also, we further discuss the prospects and outlooks of gene editing technology in disease-resistance breeding.

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