The cGAS-STING pathway in viral infections: a promising link between inflammation, oxidative stress and autophagy
文献类型： 外文期刊
作者： Zhang, Kunli 1 ; Huang, Qiuyan 2 ; Li, Xinming 2 ; Zhao, Ziqiao 1 ; Hong, Chun 2 ; Sun, Zeyi 1 ; Deng, Bo 4 ; Li, Chunling 1 ; Zhang, Jianfeng 1 ; Wang, Sutian 2 ;
作者机构： 1.Guangdong Acad Agr Sci, Key Lab Livestock Dis Prevent Guangdong Prov,Inst, Sci Observat & Expt Stn Vet Drugs & Diagnost Tech, Minist Agr & Rural Affairs,State Key Lab Swine & P, Guangzhou, Peoples R China
2.Guangdong Acad Agr Sci, Inst Anim Sci, State Key Lab Swine & Poultry Breeding Ind, Guangdong Key Lab Anim Breeding & Nutr, Guangzhou, Peoples R China
3.Guangxi Univ, Coll Anim Sci & Technol, Nanning, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Div Nephrol, Shanghai, Peoples R China
5.Maoming Branch, Guangdong Lab Lingnan Modern Agr, Maoming, Peoples R China
关键词： cGAS-STING; viral infection; innate immune; autophagy; inflammation; oxidative stress; virus-host interaction
期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：7.3； 五年影响因子：8.0 ）
ISSN： 1664-3224
年卷期： 2024 年 15 卷
页码：
收录情况： SCI
摘要： The host defence responses play vital roles in viral infection and are regulated by complex interactive networks. The host immune system recognizes viral pathogens through the interaction of pattern-recognition receptors (PRRs) with pathogen-associated molecular patterns (PAMPs). As a PRR mainly in the cytoplasm, cyclic GMP-AMP synthase (cGAS) senses and binds virus DNA and subsequently activates stimulator of interferon genes (STING) to trigger a series of intracellular signalling cascades to defend against invading pathogenic microorganisms. Integrated omic and functional analyses identify the cGAS-STING pathway regulating various host cellular responses and controlling viral infections. Aside from its most common function in regulating inflammation and type I interferon, a growing body of evidence suggests that the cGAS-STING signalling axis is closely associated with a series of cellular responses, such as oxidative stress, autophagy, and endoplasmic reticulum stress, which have major impacts on physiological homeostasis. Interestingly, these host cellular responses play dual roles in the regulation of the cGAS-STING signalling axis and the clearance of viruses. Here, we outline recent insights into cGAS-STING in regulating type I interferon, inflammation, oxidative stress, autophagy and endoplasmic reticulum stress and discuss their interactions with viral infections. A detailed understanding of the cGAS-STING-mediated potential antiviral effects contributes to revealing the pathogenesis of certain viruses and sheds light on effective solutions for antiviral therapy.
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