您好，欢迎访问江苏省农业科学院 机构知识库！
江苏省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Analysis of the recombination and evolution of the new type mutant pseudorabies virus XJ5 in China

文献类型： 外文期刊

作者： Jiang, Luyao 1 ; Cheng, Jinlong 1 ; Pan, Hao 1 ; Yang, Fan 1 ; Zhu, Xiemin 1 ; Wu, Jiayan 1 ; Pan, Haochun 1 ; Yan, Ping 1 ; Zhou, Jinzhu 1 ; Gao, Qingqing 1 ; Huan, Changchao 1 ; Gao, Song 1 ;

作者机构： 1.Yangzhou Univ, Coll Vet Med, Yangzhou 225009, Jiangsu, Peoples R China

2.Yangzhou Univ, Inst Agr Sci & Technol Dev, Coll Vet Med, Yangzhou 225009, Jiangsu, Peoples R China

3.Jiangsu Coinnovat Ctr Prevent & Control ImportantA, Yangzhou 225009, Jiangsu, Peoples R China

4.Minist Agr & Rural Affairs, Key Lab Avian Bioprod Dev, Yangzhou 225009, Jiangsu, Peoples R China

5.Yangzhou Univ, Joint Int Res Lab Agr Agriprod Safety, Minist Educ China, Yangzhou 225009, Jiangsu, Peoples R China

6.Jiangsu Acad Agr Sci, Vet Inst, Nanjing 210014, Jiangsu, Peoples R China

关键词： Pseudorabies virus; Variant strain; Phylogenetic analysis; Recombination

期刊名称：BMC GENOMICS （ 影响因子：3.5； 五年影响因子：4.1 ）

ISSN： 1471-2164

年卷期： 2024 年 25 卷 1 期

页码：

收录情况： SCI

摘要： Pseudorabies have caused enormous economic losses in China's pig industry and have recurred on many large pig farms since late 2011. The disease is caused by highly pathogenic, antigenic variant pseudorabies virus (vPRV) strains. Our laboratory isolated a pseudorabies virus in 2015 and named it XJ5. The pathogenic ability of this mutant strain was much stronger than that of the original isolate. After we sequenced its whole genome (GenBank accession number: OP512542), we found that its overall structure was not greatly changed compared with that of the previous strain Ea (KX423960.1). The whole genome alignment showed that XJ5 had a strong genetic relationship with the strains isolated in China after 2012 reported in GenBank. Based on the isolation time of XJ5 and the mutation and recombination analysis of programs, we found that the whole genome homology of XJ5 and other strains with Chinese isolates was greater than 95%, while the homology with strains outside Asia was less than 94%, which indicated that there may be some recombination and mutation patterns. We found that virulent PRV isolates emerged successively in China in 2011 and formed two different evolutionary clades from foreign isolates. At the same time, this may be due to improper immunization and the presence of wild strains in the field, and recent reports have confirmed that Bartha vaccine strains recombine with wild strains to obtain new pathogenic strains. We performed genetic evolution analysis of XJ5 isolated and sequenced in our laboratory to trace its possible mutations and recombination. We found that XJ5 may be the result of natural mutation of a virus in a branch of mutant strains widely existing in China.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：江苏省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台