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Production of bioactive compounds from callus of Pueraria thomsonii Benth with promising cytotoxic and antibacterial activities

文献类型： 外文期刊

作者： Li, Yu 1 ; Kumar, Pachaiyappan Saravana 1 ; Qiu, Jiao 2 ; Ran, Yalan 3 ; Tan, Xuhui 1 ; Zhao, Renjun 1 ; Ai, Lunqiang 1 ; Yuan, Mingyuan 1 ; Zhu, Ji 1 ; He, Meijun 1 ;

作者机构： 1.Hubei Acad Agr Sci, Inst Chinese Herbal Med, Enshi 445000, Peoples R China

2.Hubei Univ Med, Dept Cent Hosp Tujia & Miao Autonomous Prefecture, Shiyan 442000, Peoples R China

3.Agr & Rural Bur Enshi Tujia & Miao Autonomous Pre, Enshi 445000, Peoples R China

4.Hubei Minzu Univ, Coll Biol Sci & Technol, Enshi 445000, Peoples R China

关键词： Pueraria thomsonii; Callus culture; Cytotoxicity Activity; Antibacterial Activity; Bioactive compounds

期刊名称：ARABIAN JOURNAL OF CHEMISTRY （ 影响因子：6.212； 五年影响因子：5.913 ）

ISSN： 1878-5352

年卷期： 2022 年 15 卷 6 期

页码：

收录情况： SCI

摘要： For thousands of years Pueraria thomsonii Benth has been used to treat a number of diseases in traditional Chinese pharmacopeia. Despite these uses, there is still insufficient information on its biological activity and chemical composition. In this respect, the in vitro callus culture of P. thomsonii was subjected to identify anticancer and antibacterial compounds. Based on significant preliminary cytotoxicity and antibacterial activities; the chemical investigation led to the isolation of isoflavonoids, coumaric acid derivative and dihydroxyflavanone-type of compounds viz., daidzin (1), puerarin (2), biochanin A (3), daidzein (4), p-coumaric acid ethyl ester (5) and liquiritigenin (6), respectively. These compounds were tested for their cytotoxicity and antibacterial activities. Among them, p-coumaric acid ethyl ester (5) exhibited significant cytotoxicity with GI50 values of 14.73, 15.64 and 20.88 lM/mL against 4T1, NC1-H1975 and A549, respectively; the other isoflavones and aflavonoid showed moderate to weak activities. Moreover, p-coumaric acid ethyl ester (5) inhibited the growth of K. pneumonia, MRSE and MRSA at very low MIC values of 6.01, 12.01 mg/mL 24.02, respectively. On the other hand compounds biochanin A (3) and liquiritigenin (6) showed moderate antibacterial activity. Because of the potential anticancer and antibacterial activities of bioactive compounds from P. thomsonii, they can be used to treat various cancer and emerging bacterial infections. (c) 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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