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Metabolomics-guided identification of compounds with antibacterial and antioxidant activities from Polygonatum sibiricum-derived endophytic fungi

文献类型： 外文期刊

作者： Zhao, Lingyun 1 ; Liu, Yu 1 ; Sun, Huiru 1 ; Li, Yu 2 ; Pachaiyappan, Saravana Kumar 2 ; Fang, Xinyue 2 ; Ran, Yalan 3 ; Qin, Yang 4 ; Luo, Kai 1 ; He, Meijun 1 ;

作者机构： 1.Hubei MINZU Univ, Coll Biol & Food Engn, 39 Xueyuan Rd, Enshi, Peoples R China

2.Hubei Acad Agr Sci, Inst Chinese Herbal Med, 253 Xueyuan Rd, Enshi 445000, Peoples R China

3.Agr & Rural Bur Enshi Tujia & Miao Autonomous Pref, 21 Lane 1 Wuyang St, Enshi 445000, Peoples R China

4.Adm Xingdoushan Natl Nat Reserve, Enshi 445000, Peoples R China

关键词： Polygonatum sibiricum; Endophytic fungi; Secondary metabolite; Antibacterial activity; Antioxidant activity

期刊名称：BENI-SUEF UNIVERSITY JOURNAL OF BASIC AND APPLIED SCIENCES （ 影响因子：3.1； ）

ISSN：

年卷期： 2023 年 12 卷 1 期

页码：

收录情况： SCI

摘要： BackgroundInfections caused by multidrug resistant bacterial pathogens have been recognized as major global healthcare threat to medicinal, agricultural and pharmaceutical industries by World Health Organization. In this regard, the present study was aimed to isolate endophytes from medicinal plant Polygonatum sibiricum (P. sibiricum) and to investigate their antibacterial efficacy, radical scavenging ability and chemical fingerprinting using Gas Chromatography-Mass Spectrum (GC-MS) analysis. Results Two endophytic fungi Talaromyces assiutensis HJ.14 (T. assiutensis) and Fusarium oxysporum HJ.15 (F. oxysporum) were isolated and identified from the rhizomes of P. sibiricum. Among the extracts screened, ethyl acetate extract of F. oxysporum HJ.15 showed maximum antibacterial activity with the zones of inhibition ranging from 10.98 +/- 0.19 to 15.66 +/- 1.49 mm and the MIC values ranging from 0.24 to 1.88 mu g/mL against the tested bacterial pathogens. In addition, it showed significant antioxidant activity with EC50 values of 6.21-17.97 mu g/mL. Further, GC-MS analysis revealed the presence of propanoic acid ethyl ester, hexadecanoic acid methyl ester, hexadecanoic acid ethyl ester, 9-Octadecenoic acid (Z)-methyl ester, 1-Octanol, 2-Undecenal, butanoic acid, 3-hydroxy- and hexanoic acid were the most abundant compounds in the active crude extract which was responsible for the significant antibacterial and antioxidant properties. Conclusions In summary, our results clearly suggest that the F. oxysporum HJ.15 will be a promising starting point for the isolation of active antibacterial compounds with antioxidant properties.

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