Anticancer and antibacterial flavonoids from the callus of Ampelopsis grossedentata; a new weapon to mitigate the proliferation of cancer cells and bacteria
文献类型： 外文期刊
作者： Li, Yu 1 ; Kumar, Pachaiyappan Saravana 1 ; Tan, Shengquan 2 ; Huang, Chuying 2 ; Xiang, Zhixin 3 ; Qiu, Jiao 2 ; Tan, Xuhui 1 ; Luo, Jianqun 4 ; He, Meijun 1 ;
作者机构： 1.Hubei Acad Agr Sci, Inst Chinese Herbal Med, Enshi 445000, Peoples R China
2.Dept Cent Hosp Tujia & Miao Autonomous Prefecture, Enshi 445000, Peoples R China
3.Wuhan Univ, Coll Life Sci, State Key Lab Hybrid Rice, Wuhan 430072, Peoples R China
4.Enshi Selenium Commander & Ecol Agr Co, Enshi 445000, Peoples R China
期刊名称：RSC ADVANCES （ 影响因子：4.036； 五年影响因子：3.748 ）
ISSN：
年卷期： 2022 年 12 卷 37 期
页码：
收录情况： SCI
摘要： A new flavonoid angelioue (1) together with five known compounds cuminatanol (2), myricetin (3), epigallocatechin (4), taxifolin (5) and dihydromyricetin (6) was isolated from the callus extract of Ampelopsis grossedentata (Hand.-Mazz.) W. T. Wang and the structures were elucidated based on their detailed spectroscopic data. Among the compounds, the new compound angelioue (1) displayed significant antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) with the MIC value of 6.68 mu g mL(-1) and MBC value of 53.42 mu g mL(-1); in contrast the other compounds showed moderate to no antibacterial activity. In addition, known dihydromyricetin (6) exhibited potent cytotoxic activities against mouse breast cancer cells (4T1), human lung adenocarcinoma (A549) and human non-small cell lung cancer (NCI-H1975) tumor cell lines with GI50 values of 17.47, 18.91 and 20.50 mu M mL(-1), respectively. The compounds 1-5 exhibited low micro-molar inhibitory activities. Moreover, the structure-activity relationships of the most active compounds for antibacterial and cytotoxic activities are discussed. The present findings clearly suggest that the A. grossedentata callus is a good source of bioactive compounds.
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