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Pueraria thomsonii Benth-Associated Endophytes: A Multifaceted Exploration of Its Bioactive Molecules

文献类型： 外文期刊

作者： Li, Yu 1 ; Liu, Yu 1 ; Ran, Yalan 2 ; Peng, Shiqin 1 ; Yuan, Xiaoman 1 ; Zhao, Lingyun 1 ; Sun, Huiru 1 ; Su, Fulian 1 ; Huang, Donghai 1 ; Pachaiyappan, Saravana Kumar 1 ; He, Meijun 1 ;

作者机构： 1.Hubei Acad Agr Sci, Inst Chinese Herbal Med, Key Lab Biol & Cultivat Chinese Herbal Med, Minist Agr & Rural Affairs, Enshi 445000, Peoples R China

2.Agr & Rural Bur Enshi Tujia & Miao Autonomous Pre, Enshi 445000, Peoples R China

3.Hubei Minzu Univ, Coll Biol & Food Engn, Enshi 445000, Peoples R China

关键词： Endophytes; Bioactive compounds; Antibacterial; Antioxidative; Anticancer

期刊名称：INDIAN JOURNAL OF MICROBIOLOGY （ 影响因子：2.1； 五年影响因子：2.8 ）

ISSN： 0046-8991

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Endophytes associated with medicinal plants hold substantial promise as a novel source for therapeutics development. In this study, 11 endophytic fungi and 9 endophytic bacteria were isolated from the roots of Pueraria thomsonii. In the preliminary screening, the ethyl acetate extract of the Apiospora marii FG-Z21 displayed strong inhibitory effects against drug-resistant bacteria Enterococcus faecalis and Methicillin-resistant Staphylococcus aureus (MRSA) with MIC values of 1.563 and 0.098 mg/mL, respectively. Furthermore, this extract exhibited significant inhibitory effects on A549 cells with a GI(50) value of 0.036 mg/mL and demonstrated a good antioxidant property with an EC50 value of 1.869 mg/mL. Further investigation of the active ethyl acetate extract of A. marii FG-21 led to the isolation of 4-hydroxybenzoic acid (1), 2-acetamidobenzoic acid (2), benzoic acid (3), dibutyl phthalate (4), 3,4-dimethoxybenzoic acid (5), schizostatin (6), ethyl pyroglutamate (7), and anthranilic acid (8). Notably, compounds 3, 1 and 2 exhibited significant cytotoxicity against A549 cells with GI(50) values ranging from 4.97 to 83.08 mu g/mL. On the other hand, compounds 4, 5 and 6 demonstrated potent inhibition of E. faecalis growth with low MIC values ranging from 2 to 4 mu g/mL. Our study provides a comprehensive exploration of P. thomsonii-derived endophytes and their compounds highlighting their significant bacteriostatic, antioxidative, and cytotoxic activities that may potentially contribute to drug discovery paradigms.

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