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Flos populi (Male Inflorescence of Populus tomentosa Carriere) Aqueous Extract Suppresses Salmonella Pullorum Infection by Affecting T3SS-1

文献类型： 外文期刊

作者： Zhang, Wenting 1 ; Liang, Guixing 1 ; Cheng, Zhenyu 2 ; Guo, Yunqing 1 ; Jiang, Boda 1 ; Liu, Tingjiang 1 ; Liao, Weidong 1 ; Lu, Qin 1 ; Wen, Guoyuan 1 ; Zhang, Tengfei 1 ; Luo, Qingping 1 ;

作者机构： 1.Hubei Acad Agr Sci, Inst Anim Husb & Vet, Key Lab Prevent & Control Agents Anim Bacteriosis, Hubei Prov Key Lab Anim Pathogen Microbiol,Minist, Wuhan 430064, Peoples R China

2.Dalhousie Univ, Dept Microbiol & Immunol, Halifax, NS B3H 4R2, Canada

3.Hubei Hongshan Lab, Wuhan 430064, Peoples R China

关键词： Flos populi; Salmonella Pullorum; anti-infection; T3SS-1

期刊名称：PATHOGENS （ 影响因子：3.7； 五年影响因子：3.7 ）

ISSN：

年卷期： 2023 年 12 卷 6 期

页码：

收录情况： SCI

摘要： Pullorum disease, caused by Salmonella Pullorum (S. Pullorum), is one of the most serious infectious diseases in the poultry industry. Flos populi is traditionally used in Eastern Asian countries to treat various intestinal diseases. However, the anti-infection mechanism of Flos populi is not very clear. In this study, we evaluated the anti-infective effects on S. Pullorum of Flos populi aqueous extract (FPAE) in chickens. FPAE significantly reduced S. Pullorum growth in vitro. At the cellular level, FPAE reduced S. Pullorum adhesion and invasion on DF-1 cells but did not affect its intracellular survival or replication in macrophages. Further investigation revealed that FPAE inhibited the transcription of T3SS-1 genes, which is the main virulence factor that mediates S. Pullorum adhesion and invasion in host cells. The results suggest that the anti-infective effect of FPAE likely occurs through the inhibition of S. Pullorum T3SS-1, thereby impairing its ability to adhere to and invade cells. Further, we evaluated its therapeutic effect on animal models (Jianghan domestic chickens) and found that FPAE reduced the bacterial loads in organs and decreased the mortality and weight loss of infected chickens. Our findings provide novel insights into the potential development of FPAE against S. Pullorum as an effective anti-virulence therapeutic substitute for antibiotics.

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