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Genome-wide DNA methylation mediates the resistance to vibriosis in Cynoglossus semilaevis

文献类型： 外文期刊

作者： Ma, Xinran 1 ; Chen, Quanchao 1 ; Chen, Zhangfan 1 ; Chen, Songlin 1 ; Zhou, Qian 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, State Key Lab Mariculture Biobreeding & Sustainabl, Qingdao 266071, Shandong, Peoples R China

2.Shandong Key Lab Marine Fisheries Biotechnol & Gen, Qingdao 266071, Shandong, Peoples R China

3.Jiangsu Ocean Univ, Jiangsu Key Lab Marine Biol Resources & Environm, Lianyungang 222000, Peoples R China

关键词： Cynoglossus semilaevis; Kidney; Vibriosis resistance; Transcriptome; DNA methylation

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 1050-4648

年卷期： 2023 年 142 卷

页码：

收录情况： SCI

摘要： Chinese tongue sole (Cynoglossus semilaevis) is an economically important marine fish in China. However, vibriosis has caused huge mortality and economic losses in its culturing industry. To reveal the effect of DNA methylation on the resistance to vibriosis in tongue sole, we conducted RNA sequencing and whole genome bisulfite sequencing (WGBS), and compared the gene expressions and DNA methylation patterns between the resistant and susceptible families. We identified a total of 741 significantly differentially expressed genes (DEGs) in kidney and 17460 differentially methylated genes (DMGs), which were both enriched in immune-related pathways, such as "cAMP signaling pathway" and "NOD-like receptor signaling pathway". Through the corre-lation analysis of DEGs and DMGs, we identified two important immune pathways, including "complement and coagulation cascades", and "cytokine-cytokine receptor interaction", which played important roles in regulating the inflammation level and immune homeostasis. For example, the expression of proinflammatory cytokine il17c was down-regulated under the regulation of DNA methylation; in addition, the expression of protease-activated receptor 3 (par3) was up-regulated, which could induce the up-expressionof il8. These results demonstrated that the regulation of DNA methylation on the genes involved in immune responses might contribute to the resistance to vibriosis in tongue sole, and provided a basis for the control of diseases in fish aquaculture.

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