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Novel Macrolactams from a Deep-Sea-Derived Streptomyces Species

文献类型: 外文期刊

作者: Wang, Pei 1 ; Wang, Dongyang 1 ; Zhang, Rongxin 1 ; Wang, Yi 1 ; Kong, Fandong 1 ; Fu, Peng 1 ; Zhu, Weiming 1 ;

作者机构: 1.Ocean Univ China, Key Lab Marine Drugs, Minist Educ China, Sch Med & Pharm, Qingdao 266003, Peoples R China

2.Chinese Acad Trop Agr Sci, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China

3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, Qingdao 266003, Peoples R China

关键词: macrolactam; Deep-Sea-Derived Streptomyces; abiotic formation; natural product; antifungal activity

期刊名称:MARINE DRUGS ( 影响因子:5.118; 五年影响因子:5.951 )

ISSN:

年卷期: 2021 年 19 卷 1 期

页码:

收录情况: SCI

摘要: Four polyene macrolactams including the previously reported niizalactam C (4), and three new ones, streptolactams A-C (1-3) with a 26-membered monocyclic, [4,6,20]-fused tricyclic and 11,23-oxygen bridged [14,16]-bicyclic skeletons, respectively, were isolated from the fermentation broth of the deep-sea sediment-derived Streptomyces sp. OUCMDZ-3159. Their structures were determined based on spectroscopic analysis, X-ray diffraction analysis, and chemical methods. The abiotic formation of compounds 2 and 4 from compound 1 were confirmed by a series of chemical reactions under heat and light conditions. Compounds 1 and 3 showed a selective antifungal activity against Candida albicans ATCC 10231.

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