您好，欢迎访问中国热带农业科学院 机构知识库！
中国热带农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Bisabolanoic acid A, a new polychiral sesquiterpene with AChE inhibitory activity from a mangrove-derived fungus Colletotrichum sp.

文献类型： 外文期刊

作者： Li, Kun-Long 1 ; Dai, Yu 1 ; She, Jiang-Lian 1 ; Zeng, Yan-Bo 4 ; Dai, Hao-Fu 4 ; Ou, Shun-Ling 5 ; Zhou, Xue-Feng 1 ; Li 1 ;

作者机构： 1.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Peoples R China

2.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100049, Peoples R China

3.Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China

4.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China

5.Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China

6.Shenyang Pharmaceut Univ, Wuya Coll Innovat, Shenyang 110016, Peoples R China

关键词： Bisabolanoic acid A; mangrove-derived fungus; AChE inhibitory; absolute configuration

期刊名称：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH （ 影响因子：1.569； 五年影响因子：1.598 ）

ISSN： 1028-6020

年卷期：

页码：

收录情况： SCI

摘要： A new polychiral bisabolane sesquiterpene, bisabolanoic acid A (1), was isolated from the mangrove-derived fungus Colletotrichum sp. SCSIO KcB3-2. Its planar structure was identified on the basis of spectroscopic data analysis (HRESIMS, 1D, and 2D NMR), and the absolute configurations of three chiral carbons were determined by experimental and calculated electronic circular dichroism (ECD) and optical rotatory dispersion (ORD), together with Mo-2(OAc)(4)-induced ECD methods. Bisabolanoic acid A (1) showed moderate inhibitory activity against acetylcholinesterase (AChE) with IC50 value of 2.2 mu M, and the in silico molecular docking was also performed.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国热带农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台