您好，欢迎访问上海市农业科学院 机构知识库！
上海市农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Involvement of CD26 in Differentiation and Functions of Th1 and Th17 Subpopulations of T Lymphocytes

文献类型： 外文期刊

作者： Zhao, Xiangli 1 ; Wang, Wenhan 5 ; Zhang, Kai 1 ; Yang, Jingya 6 ; Fuchs, Hendrik 1 ; Fan, Hua 1 ;

作者机构： 1.Charite Univ Med Berlin, Berlin, Germany

2.Free Univ Berlin, Berlin, Germany

3.Humboldt Univ, Berlin, Germany

4.Berlin Inst Hlth, Inst Lab Med Klin Chem & Pathobiochem, Berlin, Germany

5.Shanghai Acad Agr Sci, Inst Edible Fungi, Shanghai, Peoples R China

6.Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai, Peoples R China

期刊名称：JOURNAL OF IMMUNOLOGY RESEARCH （ 影响因子：4.818； 五年影响因子：4.849 ）

ISSN： 2314-8861

年卷期： 2021 年 2021 卷

页码：

收录情况： SCI

摘要： CD26, acting as a costimulator of T cell activation, plays an important role in the immune system. However, the role of CD26 in the differentiation of T cell subsets, especially of new paradigms of T cells, such as Th17 and Tregs, is not fully clarified. In the present study, the role of CD26 in T cell differentiation was investigated in vitro. CD26 expression was analyzed in the different subsets of human peripheral blood T lymphocytes after solid-phase immobilized specific anti-CD3 mAb stimulation. Here, the percentage of CD4(+) cells significantly increased and most of these cells were coexpressed with CD26, suggesting a close correlation of CD26 expression with the proliferation of CD4(+) cells. Subsequently, after immobilized anti-CD3 mAb stimulation, CD26 high-expressing cells (CD26(high)) were separated from CD26 low-expressing cells (CD26(low)) by magnetic cell sorting. We found that the percentages of cells secreting Th1 typical cytokines (IL-2, IFN-gamma) and Th17 typical cytokines (IL-6, IL-17, and IL-22) or expressing Th17 typical biomarkers (IL-23R, CD161, and CD196) in the CD26(high) group were markedly higher than in those in the CD26(low) group. In addition, a coexpression of CD26 with IL-2, IFN-gamma, IL-17, IL-22, and IL-23R in lymphocytes was demonstrated by fluorescence microscopy. These results provide direct evidence that the high expression of CD26 is accompanied by the differentiation of T lymphocytes into Th1 and Th17, indicating that CD26 plays a crucial role in regulating the immune response.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：上海市农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台