Anti-inflammatory and intestinal microbiota modulation properties of Ganoderma lucidum ???????β-D-glucans with different molecular weight in an ulcerative colitis model
文献类型: 外文期刊
作者: Liu, Liping 1 ; Feng, Jie 1 ; Jiang, Siqi 1 ; Zhou, Shuai 1 ; Yan, Mengqiu 1 ; Zhang, Zhong 1 ; Wang, Wenhan 1 ; Liu, Yanfang 1 ; Zhang, Jingsong 1 ;
作者机构: 1.Shanghai Acad Agr Sci, Natl Engn Res Ctr Edible Fungi, Key Lab Edible Fungi Resources & Utilizat South, Minist Agr,Inst Edible Fungi, Shanghai 201403, Peoples R China
关键词: Ganoderma lucidum; beta-D-glucans; Molecular weight; Anti-inflammatory activity; Intestinal microbiota regulation; SCFAs metabolism
期刊名称:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES ( 影响因子:8.2; 五年影响因子:7.8 )
ISSN: 0141-8130
年卷期: 2023 年 251 卷
页码:
收录情况: SCI
摘要: This study systematically investigated the therapeutic effects and the corresponding mechanisms of ss-D-glucans from Ganoderma lucidum (G. lucidum) with different molecular weights (M(w)s) on ulcerative colitis (UC). Results showed that three beta-D-glucans (GLPS, GLPN and GLPW) from G. lucidum with different Mws exhibited the significant activities on the reduction of typical symptoms of UC by regulating inflammatory cytokine levels, modulating intestinal immunity, improving intestinal microbiota and metabolism of short-chain fatty acids (SCFAs) in the dextran sulfate sodium (DSS)-induced mice model. Among them, the effects of the microwave assisted degraded fraction (GLPW) mainly containing two fractions with smaller M-w (1.33 x 10(4) and 3.51 x 10(3) g/mol) on the regulation of inflammatory factors and SCFAs metabolism were found to be comparable to those of GLPN with medium M-w (3.49 x 10(4) g/mol), and superior to those of GLPS with large M-w (2.42 x 10(6) g/mol). The effect of GLPW on regulation of intestinal microbiota was even better than that of GLPN. These findings suggested that lowering M-w by means of physical degradation could improve the anti-inflammatory activities of G. lucidum beta-D-glucans. The analysis of anti-inflammatory mechanism also provided a feasible and theoretical basis for potential use of degraded beta-D-glucans in the prevention and treatment of UC.
- 相关文献
作者其他论文 更多>>
-
Anthocyanin of Black Highland Barley Alleviates H2O2-Induced Cardiomyocyte Injury and Myocardial Infarction via Activating the Phosphatase and Tensin Homolog/Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway
作者:Liu, Zhendong;Shu, Senbiao;Li, Simin;Peng, Pai;Zhang, Ying;Li, Zhaohua;Wang, Wenhan
关键词:cardiovascular disease; black barley; anthocyanin; oxidative stress; PTEN/PI3K/Akt pathway
-
Revealing the ACE receptor binding properties and interaction mechanisms of salty oligopeptides from Stropharia rugosoannulata mushroom by molecular simulation and antihypertensive evaluation
作者:Li, Wen;Chen, Wanchao;Zhang, Zhong;Wu, Di;Liu, Peng;Li, Zhengpeng;Yang, Yan;Li, Wen;Chen, Wanchao;Zhang, Zhong;Wu, Di;Liu, Peng;Li, Zhengpeng;Yang, Yan;Li, Wen;Ma, Haile;Wang, Jinbin
关键词:
-
Liquid-Phase Adsorption Behavior of β-D-Glucooligosaccharides When Using Activated Carbon for Separation, and the Antioxidant Stress Activity of Purified Fractions
作者:Ma, Guan-Hua;Jiang, Si-Qi;Liu, Li-Ping;Feng, Jie;Zhang, Jing-Song;Liu, Yan-Fang;Li, E-Xian;Li, Shu-Hong
关键词:beta-glucooligosaccharides; adsorption mechanism; separation; antioxidative stress activity
-
Resveratrol-loaded sulfated Hericium erinaceus p-glucan-chitosan nanoparticles: Preparation, characterization and synergistic anti-inflammatory effects
作者:Zhang, Zhong;Wu, Di;Li, Wen;Chen, Wanchao;Liu, Peng;Yang, Yan;Ge, Meili;Zhang, Haiyun
关键词:Resveratrol; Sulfated Hericium erinaceus p-glucan; Nanoparticles; Anti-inflammatory activity; Synergistic effect
-
Structural Elucidation of a Polysaccharide from Flammulina velutipes and Its Lipid-Lowering and Immunomodulation Activities
作者:Jia, Wei;Wang, Wenhan;Yu, Dongsheng;Zhang, Jingsong;Zhang, Henan;Jia, Wei;Wang, Wenhan;Yu, Dongsheng;Zhang, Jingsong;Zhang, Henan;Yu, Yangchao;Feng, Zhan;Li, Hewen
关键词:Flammulina velutipes; polysaccharides; three-phase partitioning; structural characteristics; lipid-lowering activity; immunoregulatory activity
-
Stereo-selective cardiac toxicity induced by metconazole via oxidative stress and the wnt/β-catenin signaling pathway in zebrafish embryos
作者:Liu, Lulu;Wang, Fengzhong;Fan, Bei;Li, Lin;Zhang, Yifan;Yan, Zhihui;Li, Minmin;Liu, Lulu;Zhang, Zhong;Luo, Ying;Kong, Zhiqiang;Francis, Frederic
关键词:cis -Metconazole; Zebrafish; Stereoselective cardiotoxicity; Oxidative stress; Wnt/ss-catenin signaling pathway
-
Exploring the taste presentation and receptor perception mechanism of salty peptides from Stropharia rugosoannulata based on molecular dynamics and thermodynamics simulation
作者:Li, Wen;Chen, Wanchao;Zhang, Zhong;Wu, Di;Yan, Mengqiu;Yang, Yan;Li, Wen;Sun, Shuai;Ma, Haile;Li, Tingzhao;Li, Tingzhao
关键词:Salty peptide; Molecular docking; Biolayer interferometry; Isothermal titration calorimetry