您好，欢迎访问上海市农业科学院 机构知识库！
上海市农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Structure and Activity of β-Oligosaccharides Obtained from Lentinus edodes (Shiitake)

文献类型： 外文期刊

作者： Jia, Wei 1 ; Wang, Wenhan 1 ; Yu, Yanzhen 3 ; Wang, Huimin 4 ; Zhang, Hongtao 5 ; Liu, Peng 1 ; Zhang, Meiyan 1 ; Li, Qiaozhen 1 ; Zhang, Henan 1 ; Li, Huaxiang 6 ; Zhang, Jingsong 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Inst Edible Fungi, Shanghai 201403, Peoples R China

2.Shanghai Guosen Biotech Co Ltd, Shanghai 201403, Peoples R China

3.Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai 201306, Peoples R China

4.Shanghai Hengrui Pharmaceut Co Ltd, Shanghai 200245, Peoples R China

5.Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Peoples R China

6.Yangzhou Univ, Sch Food Sci & Engn, Yangzhou 225127, Peoples R China

关键词： Lentinus edodes; beta-oligosaccharide; structure; activity; dectin-1

期刊名称：SEPARATIONS （ 影响因子：2.7； 五年影响因子：2.7 ）

ISSN：

年卷期： 2024 年 11 卷 11 期

页码：

收录情况： SCI

摘要： The structure and characteristics of LEOPs, beta-oligosaccharides from the fruiting body of Lentinus edodes obtained via acid degradation and gel permeation chromatography, were investigated. We performed high-performance liquid chromatography, infrared spectroscopy, methylation analysis, nuclear magnetic resonance, and correlated activity experiments, including antioxidant, immunomodulatory, and liver injury protection to gain insights. LEOPs comprised an oligosaccharide (Mw 2445 Da) based on six beta-1, 3-D-glucose residues as the main chain and six beta-1, 6-D-glucose residues as the side chain. Surface plasmon resonance analysis indicated that LEOPs directly bound to dectin-1, which facilitated their immunoenhancing activity via downstream NF-kappa B activation. The results implied that LEOPs may be the active unit of the shiitake beta-glucan. The determination of LEOPs structure was performed to reveal the anti-tumor effect and immune-regulatory function of shiitake beta-glucan on a molecular level to provide a basis.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：上海市农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台