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Two new 2-(2-phenethyl)chromone derivatives from agarwood of Aquilaria walla and their cytotoxicity

文献类型: 外文期刊

作者: Wang, Yue-Yue 1 ; Wang, Hao 2 ; Mi, Cheng-Neng 2 ; Li, Wei 2 ; Gai, Cui-Juan 2 ; Yuan, Jing-Zhe 2 ; Mei, Wen-Li 2 ; Xu, S 1 ;

作者机构: 1.Hainan Univ, Coll Trop Agr, Haikou 570228, Hainan, Peoples R China

2.Chinese Acad Trop Agr Sci, Hainan Engn Res Ctr Agarwood, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Hainan, Peoples R China

3.Hainan Univ, Coll Hort, Haikou 570228, Hainan, Peoples R China

关键词: Aquilaria walla; Agarwood; Dimeric 2-(2-phenethyl)chromone; Flavonoid-2-(2-phenethyl)chromone; Cytotoxicity

期刊名称:PHYTOCHEMISTRY LETTERS ( 影响因子:1.459; 五年影响因子:1.601 )

ISSN: 1874-3900

年卷期: 2021 年 42 卷

页码:

收录情况: SCI

摘要: Two new 2-(2-phenethyl)chromone derivatives were isolated from agarwood of Aquilaria walla, including a dimeric 2-(2-phenethyl)chromone (1) and a flavonoid-2-(2-phenethyl)chromone (2). Their structures were established based on spectroscopic methods including HRESIMS, 1D, and 2D NMR. Compounds 1 and 2 showed cytotoxic activity against five human cancer cell lines with IC50 values ranging from 4.96?44.34 ?M.

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