文献类型： 外文期刊
作者： Thu, Zaw Min 1 ; Sun, Jian 1 ; Ji, Jingwen 1 ; He, Lili 1 ; Ji, Jinbo 1 ; Iqbal, Zafar 1 ; Myo, Ko Ko 1 ; Gao, Yuanyu 1 ; Zh 1 ;
作者机构： 1.Ningxia Acad Agr & Forestry Sci, Ningxia Ctr Organ Synth & Engn Technol, 590 Huanghe East Rd, Yinchuan 750002, Ningxia, Peoples R China
2.Kalay Univ, Dept Chem, Kalay 03044, Sagaing Region, Myanmar
3.Tishk Int Univ, Fac Sci, Med Anal Dept, Erbil 44001, Kurdistan Regio, Iraq
关键词： Monobactam; Aztreonam; Antibacterial; Gram-negative
期刊名称：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS （ 影响因子：2.572； 五年影响因子：2.427 ）
ISSN： 0960-894X
年卷期： 2021 年 39 卷
页码：
收录情况： SCI
摘要： Monobactams play an important role in antibiotic drug discovery. Based on the structural characteristics of aztreonam and its biological targets, six new monobactam derivatives (2a-c and 3a-c) were synthesized and their in vitro antibacterial activities were investigated. Compounds 2a-c showed higher activities against tested gramnegative bacteria than that of parent aztreonam. Monobactam 2c exhibited the most potent activities, with MIC ranging from 0.25 to 2 jig/mL against most bacteria.
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