文献类型： 外文期刊
作者： Thu, Zaw Min 1 ; Sun, Jian 1 ; Ji, Jingwen 1 ; He, Lili 1 ; Ji, Jinbo 1 ; Iqbal, Zafar 1 ; Myo, Ko Ko 1 ; Gao, Yuanyu 1 ; Zh 1 ;
作者机构： 1.Ningxia Acad Agr & Forestry Sci, Ningxia Ctr Organ Synth & Engn Technol, 590 Huanghe East Rd, Yinchuan 750002, Ningxia, Peoples R China
2.Kalay Univ, Dept Chem, Kalay 03044, Sagaing Region, Myanmar
3.Tishk Int Univ, Fac Sci, Med Anal Dept, Erbil 44001, Kurdistan Regio, Iraq
关键词： Monobactam; Aztreonam; Antibacterial; Gram-negative
期刊名称：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS （ 影响因子：2.572； 五年影响因子：2.427 ）
ISSN： 0960-894X
年卷期： 2021 年 39 卷
页码：
收录情况： SCI
摘要： Monobactams play an important role in antibiotic drug discovery. Based on the structural characteristics of aztreonam and its biological targets, six new monobactam derivatives (2a-c and 3a-c) were synthesized and their in vitro antibacterial activities were investigated. Compounds 2a-c showed higher activities against tested gramnegative bacteria than that of parent aztreonam. Monobactam 2c exhibited the most potent activities, with MIC ranging from 0.25 to 2 jig/mL against most bacteria.
- 相关文献
作者其他论文 更多>>
-
Ruthenium-catalyzed reaction of dinitriles with primary alcohols for the synthesis of N-alkylated cyclic β-enaminonitriles
作者：Ma, Wei;Zhao, Qiang;Su, Shibin;Zhang, Weiwei;Yao, Yao;Wang, Pei;Tang, Dong;Zhou, Pengjuan
关键词：N-alkylated cyclic beta-enaminonitriles; aliphatic dinitrile; primary alcohol; ruthenium-catalyzed
-
Base-Catalyzed Cascade Cyclization of Acyl Cyanides and Isocyanates for the Synthesis of Oxazoles
作者：Zhang, Wei;Li, Hongjun;Hou, Jing;Wan, Yaya;Zhou, Pengjuan;Tang, Dong
关键词：Acyl cyanides; Base-promoted; Cyclization reaction; Oxazoles; Isocyanates
-
Electrochemical Selenylation-Induced Oxyselenation of Alkene Derivatives for the Synthesis of β-Hydroxyselenides
作者：Huang, Ruimin;Zhou, Ruichen;Hou, Guoan;Hou, Jing;Wan, Yaya;Zhou, Pengjuan;Tang, Dong
关键词：Diselenides; Electrosynthesis; Oxyselenation; Styrene; beta-Hydroxyselenides
-
Synergism between Surface Engineering and S-Scheme Heterojunctions for Efficient Photocatalytic H2 Evolution
作者：Guo, Xin;Wen, Bo;Liu, Jiayue;Jin, Zhiliang;Tang, Dong;Li, Youji
关键词：
-
Selected Electrosynthesis of 3-Aminopyrazoles from α,β-Alkynic Hydrazones and Secondary Amines
作者：Tang, Dong;Zhang, Wei;Ji, Jingwen;Jiang, Rui;Wan, Yaya;Zhou, Pengjuan;Ma, Wei
关键词：
-
Synthesis of N1-caffeoyl-N10-dihydrocaffeoylspermidine (Scotanamine D)
作者：Ji, Jingwen;Iqbal, Zafar;Sun, Jian;Zhou, Pengjuan;Zhai, Lijuan;He, Lili;Tang, Dong;Ji, Jinbo;Yang, Haikang;Yang, Zhixiang;Li, Liuyan
关键词：N1-caffeoyl-N10-dihydrocaffeoylspermidine; spermidine; alkaloid; yields; medicinally valuable; natural compound; synthesis
-
Convenient Synthesis of Bis-(Dihydro)Caffeoylspermine
作者：Zhai, Lijuan;Sun, Jian;Zhou, Pengjuan;Ji, Jingwen;He, Lili;Tang, Dong;Ji, Jinbo;Yang, Haikang;Iqbal, Zafar;Yang, Zhixiang
关键词：kukoamine A; natural product; dihydrocaffeic acid; spermine
