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Mechanisms of parental co-exposure to polystyrene nanoplastics and microcystin-LR aggravated hatching inhibition of zebrafish offspring

文献类型： 外文期刊

作者： Wu, Qin 2 ; Li, Guangyu 3 ; Huo, Tangbin 6 ; Du, Xue 6 ; Yang, Qing 7 ; Hung, Tien-Chieh 8 ; Yan, Wei 1 ;

作者机构： 1.Hubei Acad Agr Sci, Inst Qual Stand & Testing Agrpprod, Wuhan 430064, Peoples R China

2.Hubei Normal Univ, Hubei Key Lab Edible Wild Plants Conservat & Utli, Huangshi 435002, Hubei, Peoples R China

3.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China

4.Hubei Key Lab Nutr Qual & Safety Agroprod, Wuhan 430064, Hubei, Peoples R China

5.Hubei Engn Res Ctr Special Wild Vegetables Breedi, Huangshi 435002, Peoples R China

6.Chinese Acad Fishery Sci, Heilongjiang River Fishery Res Inst, Harbin 150010, Peoples R China

7.Minist Water Resources & Chinese Acad Sci, Inst Hydroecol, Key Lab Ecol Impacts Hydraul Projects & Restorat, Minist Water Resources, Wuhan 430079, Hubei, Peoples R China

8.Univ Calif Davis, Dept Biol & Agr Engn, Davis, CA 95616 USA

关键词： Embryonic hatching inhibition; Co-exposure; Microcystins-LR; Polystyrene nanoplastics; Mechanisms

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：6.551； 五年影响因子：6.419 ）

ISSN： 0048-9697

年卷期： 2021 年 774 卷

页码：

收录情况： SCI

摘要： The combined toxicity effects of microcystins-LR (MCLR) and polystyrene nanoplastics (PSNPs) on the hatching of F1 zebrafish (Danio rerio) embryos were investigated in this study due to the increasing concerns of both plastic pollution and eutrophication in aquatic environments. Three-month-old zebrafish were used to explore the molecular mechanisms underlying the combined effect of MCLR (0, 0.9, 4.5, and 22.5 mu g/L) on egg hatching in the existence of PSNPs (100 mu g/L). The results demonstrated the existence of PSNPs further increased the accumulation of MCLR in F1 embryos. The hatching rates of F1 embryos were inhibited after exposure to 22.5 mu g/L MCLR, and the presence of PSNPs aggravated the hatching inhibition induced by MCLR. The decrease of hatching enzyme activity and the abnormality of spontaneous movement were observed. We examined the altered expression levels of the genes associated with the hatching enzyme (tox16, foxp1, ctslb, xpb1, klf4, cap1, bmp4, cd63, He1.2, zhe1, and prl), cholinergic system (ache and chrn alpha 7), and muscle development (Wnt, MyoD, Myf5, Myogenin, and MRF4). The results suggested the existence of PSNPs exacerbated the hatching inhibition of F1 embryos through decreasing the activity of enzyme, interfering with the cholinergic system, and affecting the muscle development. (C) 2021 Published by Elsevier B.V.

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