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Quantitative proteomic analysis reveals that serine/threonine kinase is involved in Streptococcus suis virulence and adaption to stress conditions

文献类型： 外文期刊

作者： Zhu, Haodan 1 ; Zhou, Junming 1 ; Wang, Dandan 1 ; Yu, Zhengyu 1 ; Li, Bin 1 ; Ni, Yanxiu 1 ; He, Kongwang 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing, Peoples R China

2.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Jiangsu, Peoples R China

3.State Key Lab Breeding Base, Key Lab Food Qual & Safety Jiangsu Prov, Nanjing, Peoples R China

关键词： Streptococcus suis; Serine; threonine kinase; Quantitative proteomic; Virulence; Stress

期刊名称：ARCHIVES OF MICROBIOLOGY （ 影响因子：1.884； 五年影响因子：1.835 ）

ISSN： 0302-8933

年卷期：

页码：

收录情况： SCI

摘要： The eukaryotic-type serine/threonine kinase of Streptococcus suis serotype 2 (SS2) performs critical roles in bacterial pathogenesis. In this study, isobaric tags for relative and absolute quantification (iTRAQ) MS/MS were used to analyze the protein profiles of wild type strain SS2-1 and its isogenic STK deletion mutant (Delta stk). A total of 281 significant differential proteins, including 147 up-regulated and 134 down-regulated proteins, were found in Delta stk. Moreover, 69 virulence factors (VFs) among these 281 proteins were predicted by the Virulence Factor Database (VFDB), including 38 downregulated and 31 up-regulated proteins in Delta stk, among which 15 down regulated VFs were known VFs of SS2. Among the down-regulated proteins, high temperature requirement A (HtrA), glutamine synthase (GlnA), ferrichrome ABC transporter substrate-binding protein FepB, and Zinc-binding protein AdcA are known to be involved in bacterial survival and/or nutrient and energy acquisition under adverse host conditions. Overall, our results indicate that STK regulates the expression of proteins involved in virulence of SS2 and its adaption to stress environments.

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