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Expression, secretion and bactericidal activity of type VI secretion system in Vibrio anguillarum

文献类型： 外文期刊

作者： Tang, Lei 1 ; Yue, Shu 1 ; Li, Gui-Yang 2 ; Li, Jie 2 ; Wang, Xiao-Ran 1 ; Li, Shu-Fang 2 ; Mo, Zhao-Lan 2 ;

作者机构： 1.Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Peoples R China

2.Chinese Acad Fishery Sci, Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Minist Agr,Yellow Sea Fisheries Res Inst,Key Lab, Qingdao 266071, Peoples R China

关键词： Vibrio anguillarum; T6SS; Hcp; Bactericidal activity

期刊名称：ARCHIVES OF MICROBIOLOGY （ 影响因子：2.552； 五年影响因子：2.475 ）

ISSN： 0302-8933

年卷期： 2016 年 198 卷 8 期

页码：

收录情况： SCI

摘要： The type VI secretion system (T6SS) was recently shown to modulate quorum sensing and the stress response in Vibrio anguillarum serotype O1 strain NB10. It is not known whether there is a functionally active T6SS in other serotypes of V. anguillarum. Here, homologues to T6SS cluster VtsEFGH and hemolysin-coregulated protein (Hcp)-encoding genes were found to be prevalent and conserved in clinical isolates of V. anguillarum from fish, including four O1 and five non-O1 serotype strains. Unexpectedly, only the non-O1 serotype strains expressed VtsEFGH and Hcp under laboratory and marine-like conditions, in contrast to the serotype O1 strains. This suggested that the V. anguillarum non-O1 serotype strains tested have constitutive expression of T6SS. Examination of a representative non-O1 strain, MHK3, showed that Hcp production was growth phase dependent and that maximum Hcp production was observed in the exponential growth phase. Moreover, Hcp production by MHK3 was most active under warm marine-like conditions. Further examination revealed a correlation of the constitutive expression of T6SS with bactericidal activity against Escherichia coli and Edwardsiella tarda. The work presented here suggests that the constitutive expression of T6SS provides V. anguillarum with advantage in microbial competition in marine environments.

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