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Effects of Saccharomyces cerevisiae on alleviating cytotoxicity of porcine jejunal epithelia cells induced by deoxynivalenol

文献类型： 外文期刊

作者： Liu, Yang 1 ; Chang, Juan 1 ; Wang, Ping 1 ; Yin, Qing-qiang 1 ; Huang, Wei-wei 1 ; Liu, Chao-qi 1 ; Bai, Xian-xiao 2 ; Z 1 ;

作者机构： 1.Henan Agr Univ, Coll Anim Sci & Vet Med, Zhengzhou 40002, Henan, Peoples R China

2.Henan Acad Agr Sci, Inst Anim Husb & Vet Sci, Zhengzhou 450002, Henan, Peoples R China

3.Henan Delin Biol Prod Co Ltd, Xinxiang 453000, Henan, Peoples R China

4.Henan Guangan Biotechnol Co Ltd, Zhengzhou 450001, Henan, Peoples R China

5.Wugang Anim Prod Qual Inspect Ctr, Wugang 467000, Peoples R China

关键词： Deoxynivalenol; Detoxification; Saccharomyces cerevisiae; IPEC-J2; Cytotoxicity

期刊名称：AMB EXPRESS （ 影响因子：3.298； 五年影响因子：3.427 ）

ISSN： 2191-0855

年卷期： 2019 年 9 卷 1 期

页码：

收录情况： SCI

摘要： Deoxynivalenol (DON) is one of the mycotoxins most frequently encountering in cereal-based foods throughout the world. Saccharomyces cerevisiae was used to alleviate porcine jejunal epithelia cell (IPEC-J2) injury induced by DON in this study. The results indicated that cell viability and proliferation rates were significantly decreased when DON concentrations were increased from 0 to 64 mu M after 24 h incubation (p < 0.05). The longer incubation time and higher DON concentrations would cause more serious effects on cell viability. S. cerevisiae could significantly degrade DON and decrease lactic dehydrogenase (LDH) release in the cells induced by DON (p < 0.05). DON (4 mu M) could increase necrotic and apoptotic cell rates as well as decrease viable cell rates, compared with the control group (p < 0.05). However, S. cerevisiae addition in the DON group could decrease necrotic, late apoptotic and early apoptotic cell rates by 38.05%, 46.37% and 44.78% respectively, increase viable cell rates by 2.35%, compared with the single DON group (p < 0.05). In addition, S. cerevisiae addition could up-regulate mRNA abundances of IL-6, IL-8 and IL-10 in IPEC-J2 cells (p < 0.05), but down-regulate mRNA abundances of tight junction proteins (TJP-1) and occludin by 36.13% and 50.18% at 1 mu M of DON (p < 0.05). It could be concluded that S. cerevisiae was able to alleviate IPEC-J2 cell damage exposed to DON.

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